29480-09-9

Basic information

• Product Name: Cyclobutanol, 1-(4-chlorophenyl)-
• CAS NO: 29480-09-9
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Mol File: 29480-09-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Cyclobutanol, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanol, 1-(4-chlorophenyl)-(29480-09-9)
• EPA Substance Registry System: Cyclobutanol, 1-(4-chlorophenyl)-(29480-09-9)

Safety Data

• Hazardous Substances Data: 29480-09-9(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 1191-95-3 cyclobutanone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-46-7 para-dichlorobenzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 29510-73-4 1-Chloro-4-(1-chloro-cyclobutyl)-benzene 
• 189079-77-4 4-Azido-1-(4-chloro-phenyl)-butan-1-one 
• 22217-78-3 5-(4-chlorophenyl)-3,4-dihydro-2H-pyrrole 
• 50921-39-6 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid 
• 26086-96-4 1,8-bis(4-chlorophenyl)octane-1,8-dione 

Relevant articles and documents

Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH3OTf

The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH3OTf) has been developed. This one-pot procedure achieves C–N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthes

Synthesis of 1-Pyrroline by Denitrogenative Ring Expansion of Cyclobutyl Azides under Thermal Conditions

We herein report an efficient and systematic synthesis of 1-pyrrolines from cyclobutyl azides under thermal and neutral conditions. The reaction proceeded without any additional reagents, and nitrogen was generated as the sole by-product. Furthermore, the generated 1-pyrrolines could be continuously transformed into pyrroles, N-Boc-amines, and oxaziridines in an one-pot manner. (Figure presented.).

Catalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments

gem-Diarylheterocycles display a wide range of biological activity. Here we present a systematic study into the formation of 4- to 6-membered O- and N-heterocycles and cyclobutanes bearing the diaryl motif through a catalytic Friedel–Crafts reaction from the corresponding benzylic alcohols. 3,3-Diaryltetrahydrofurans, 4,4-diaryltetrahydropyrans, 3,3-diarylpyrrolidines, 4,4-diaryl-piperidines, as well as diarylcyclobutanes are examined, with results for 3,3-diaryloxetanes and 3,3-diarylazetidines presented for comparison. Three catalytic systems are investigated for each substrate [Ca(II), Li(I) and Fe(III)], across preinstalled aromatic groups of differing electronic character. In most cases examined, the diaryl product is obtained directly from the alcohol with good yields using the most appropriate catalyst system. In the absence of a nucleophile, the olefins from the 5- and 6-membered substrates by elimination of water are obtained under the same reaction conditions.