294866-41-4Relevant articles and documents
Discovery of cysteine and its derivatives as novel antiviral and antifungal agents
Lu, Aidang,Shi, Li,Wang, Tienan,Wang, Ziwen,Yang, Shan,Zhou, Yanan
, (2021/06/25)
Based on the structure of the natural product cysteine, a series of thiazolidine-4-carboxylic acids were designed and synthesized. All target compounds bearing thiazolidine-4-carboxylic acid were characterized by1 H-NMR,13 C-NMR, and
Chemically controlled amplified ratiometric fluorescence in surface-immobilized end-capped oligo(p-phenylene ethynylene)s
Acharya, Jiba Raj,Zhang, Huating,Li, Xian,Nesterov, Evgueni E.
supporting information; experimental part, p. 880 - 881 (2009/06/19)
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Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer
Gududuru, Veeresa,Hurh, Eunju,Dalton, James T.,Miller, Duane D.
, p. 2584 - 2588 (2007/10/03)
To improve the selectivity and antiproliferative activity of previously reported serine amide phosphates (SAPs), we designed a new series of 4-thiazolidinone amides, in which the 4-thiazolidinone moiety was introduced as a phosphate mimic. However, these 4-thiazolidinone derivatives demonstrated less cytotoxicity in prostate cancer cells despite improved selectivity over RH7777 cells. To further optimize the thiazolidinone analogues in terms of cytotoxicity and selectivity, we made closely related structural modifications, which led us to the discovery of a new class of 2-arylthiazolidine-4-carboxylic acid amides. These compounds were potent cytotoxic agents with IC50 values in the low micromolar concentration range and demonstrated enhanced selectivity in receptor-negative cells compared to SAPs and 4-thiazolidinone amides.