2953-58-4

Basic information

• Product Name: N,N-dimethyl-4-chloro-2-nitrobenzamide
• Synonyms: N,N-dimethyl-4-chloro-2-nitrobenzamide
• CAS NO: 2953-58-4
• Molecular Weight: 228.635
• Mol File: 2953-58-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-4-chloro-2-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-chloro-2-nitrobenzamide(2953-58-4)
• EPA Substance Registry System: N,N-dimethyl-4-chloro-2-nitrobenzamide(2953-58-4)

Safety Data

• Hazardous Substances Data: 2953-58-4(Hazardous Substances Data)

Upstream product

• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

Method for synthesizing phosphorus-oxychloride-promoted amide compound

The invention relates to a method for synthesizing a phosphorus-oxychloride-promoted amide compound. The synthesizing method includes the steps that carboxylic acid serves as one reactant, another reactant (N,N-dialkyl methanamide) serves as a solvent, one equivalent of phosphorus oxychloride is added, and the amide compound is prepared. The reaction substrates are low in price and easy to get, the nature is stable, toxicity is small, the reaction speed is high, conditions are moderate, and the reaction substrates can be widely applied to substrates with different functional groups. The efficiently-constructed amide compound is an important molecular skeleton for many medicines, bioactive molecules and natural products, and the synthesizing method is a widely-applicable preparing method for synthesizing the compound.