295345-23-2Relevant articles and documents
A facile three-component one-pot synthesis of structurally constrained tetrahydrofurans that are t-RNA synthetase inhibitor analogues
Lu, Chong-Dao,Chen, Zhi-Yong,Liu, Hui,Hu, Wen-Hao,Mi, Ai-Qiao,Doyle, Michael P.
, p. 4856 - 4859 (2007/10/03)
A one-pot procedure for the efficient synthesis of tRNA inhibitor analogues was developed. Thus, three-component 1,3-dipolar cycloaddition reactions of carbonyl ylides derived from diazoindan-1,3-dione and aldehydes with other dipolarophiles in 1,1,2,2-tetrachloroethane in 80 °C gave ring-fused tetrahydrofurans having three stereocenters in good yield.