2960-55-6

Basic information

• Product Name: [(E)-4-Nitrostyryl]phenyl ketone
• Synonyms: 4-Nitro-trans-chalcone;(E)-1-Phenyl-3-(4-nitrophenyl)-2-propene-1-one;(E)-4-Nitrochalcone;[(E)-4-Nitrostyryl]phenyl ketone
• CAS NO: 2960-55-6
• Molecular Formula: C₁₅H₁₁NO₃
• Molecular Weight: 253.2527
• Mol File: 2960-55-6.mol
• Article Data: 107

Chemical Properties

• Melting Point: 164-164.5 °C
• Boiling Point: 399.2°Cat760mmHg
• Flash Point: 186.5°C
• Appearance: /
• Density: 1.255g/cm³
• CAS DataBase Reference: [(E)-4-Nitrostyryl]phenyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-4-Nitrostyryl]phenyl ketone(2960-55-6)
• EPA Substance Registry System: [(E)-4-Nitrostyryl]phenyl ketone(2960-55-6)

Safety Data

• Hazardous Substances Data: 2960-55-6(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 2929-91-1 4-nitrobenzylidene diacetate 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 38895-96-4 p-nitrochalcone dibromide 
• 1222-98-6 3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 111873-49-5 Te-phenacyldi(n-butyl)telluronium bromide 
• 683-08-9 Diethyl methylphosphonate 
• 100-47-0 benzonitrile 
• 38788-38-4 dibutyl telluride 
• 34063-53-1 p-nitrobenzyl phenyl sulfone 
• 110661-61-5 (p-nitrophenyl)methanesulfonyl fluoride 

Downstream Products

• 171860-01-8 diethyl 2-(1-(4-nitrophenyl)-3-oxo-3-phenylpropyl)malonate 
• 109747-18-4 (2RS,3RS)-2-bromo-3-morpholino-3-(4-nitro-phenyl)-1-phenyl-propan-1-one 
• 20087-21-2 [5t-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-isoxazol-4r-yl]-phenyl ketone 
• 20087-22-3 (+/-)-[4t-(4-nitro-phenyl)-3-phenyl-4,5-dihydro-isoxazol-5r-yl]-phenyl ketone 
• 131497-22-8 4,3'-dinitro-trans-chalcone 
• 1222-98-6 3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 38239-54-2 trans-1-(4-aminophenyl)-3-phenyl-1-propen-3-one 
• 101352-03-8 4-nitro-chalcone semicarbazone 
• 17245-24-8 (+/-)-3t-(4-nitro-phenyl)-1-phenyl-allyl alcohol 
• 17245-00-0 (+/-)-1-(4-nitro-phenyl)-3t-phenyl-allyl alcohol 
• 115915-45-2 1r,3t-dibenzoyl-2c,4t-bis-(4-nitro-phenyl)-cyclobutane 
• 684239-31-4 4-(4-nitro-phenyl)-2-phenyl-6,7-dihydro-5H-[1]pyrindine 
• 13736-27-1 4-nitro-trans-chalcone-phenylhydrazone 
• 6969-06-8 1,5-Diphenyl-3-(4-nitrophenyl)-2-pyrazoline 

Relevant articles and documents

Mechanochemical Syntheses of N-Containing Heterocycles with TosMIC

A mechanochemical van Leusen pyrrole synthesis with a base leads to 3,4-disubstitued pyrroles in moderate to excellent yields. The developed protocol is compatible with a range of electron-withdrawing groups and can also be applied to the synthesis of oxazoles. Attempts to mechanochemically convert the resulting pyrroles into porphyrins proved to be difficult.

Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B

A library of monosubstituted chalcones (1-17) bearing electron-donating and electron-withdrawing groups on both aromatic rings were selected. The cell viability on human tumor cell lines was evaluated first. The compounds unable to induce detectable cytotoxicity (1, 13, and 14) were tested using the monoamine oxidase (MAO) activity assay. Interestingly, they inhibit MAO-B, acting as competitive inhibitors, with 13 and 14 showing the best profiles. In particular, 13 exhibited a potency higher than that of safinamide, taken as a reference. Docking studies and crystallographic analysis showed that in human MAO-B 13 binds with the halogen-substituted aromatic ring in the entrance cavity, similar to safinamide, whereas 14 is accommodated in the opposite way. The main conclusion of this cell biology, biochemistry, and structural study is to highlights 13 as a chalcone derivative that is worth consideration for the development of novel MAO-B-selective inhibitors for the treatment of neurodegenerative diseases.

COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE

The present invention relates to the discovery of novel compounds that can be used to treat and/or prevent heart failure in a subject. In certain embodiments, the compounds of the invention are sulfide: quinone oxidoreductase (SQOR) inhibitors. In other e