29600-34-8Relevant articles and documents
Facile Synthesis of N-Substituted-4-cyano-4-phenylpiperidines via Phase-Transfer Catalysis
Thompson, Doug,Reeves, Perry C.
, p. 771 - 772 (2007/10/02)
Phenylacetonitrile can be condensed with N-substituted-bis(2-chloroethyl)amines in aqueous sodium hydroxide solution to produce N-substituted-4-cyano-4-phenylpiperidines.Hexadecyltributylphosphonium bromide is an effective catalyst for this phase-transfer reaction.