296280-56-3

Basic information

• Product Name: N-(2-{7-[3-({8-[2-(acetylamino)ethyl]-2-naphthyl}oxy)propoxy]-1-naphthyl}-ethyl)acetamide
• CAS NO: 296280-56-3
• Molecular Weight: 498.622
• Mol File: 296280-56-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 113-116 °C(Solv: toluene (108-88-3))
• Boiling Point: 804.6±65.0 °C(Predicted)
• Density: 1.168±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-(2-{7-[3-({8-[2-(acetylamino)ethyl]-2-naphthyl}oxy)propoxy]-1-naphthyl}-ethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-{7-[3-({8-[2-(acetylamino)ethyl]-2-naphthyl}oxy)propoxy]-1-naphthyl}-ethyl)acetamide(296280-56-3)
• EPA Substance Registry System: N-(2-{7-[3-({8-[2-(acetylamino)ethyl]-2-naphthyl}oxy)propoxy]-1-naphthyl}-ethyl)acetamide(296280-56-3)

Safety Data

• Hazardous Substances Data: 296280-56-3(Hazardous Substances Data)

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 152302-45-9 N-[2-(7-Hydroxy-1-naphthyl)ethyl]-acetamide 

Relevant articles and documents

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

We report the synthesis and binding properties at MT1 and MT2 receptors of the first example of agomelatine (N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide) dimers in which two agomelatine moieties are linked together through their methoxy substituent by a polymethylene side chain according to the bivalent ligand approach. Some of these compounds behave as MT1-selective ligands. The most selective one (5) behaves as an antagonist.

Substituted dimeric compounds

The invention relates to compounds of formula (I): A—G1—Cy—G2—Cy—G3—B??(I) wherein: A represents NR1C(Q)R2, C(Q)NR2R3or NR1C(Q)NR2R3, B represents NR1C(Q)R2, C(Q)NR2R3, NR1C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2or NR2R3, G1and G3represent an optionally substituted alkylene chain, Cy represents a ring structure and G2 represents a chain and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.