29638-63-9

Basic information

• Product Name: 1-(butylamino)-3-phenoxypropan-2-ol
• Synonyms: 1-(Butylamino)-3-phenoxypropan-2-ol; 1-Butylamino-3-phenoxy-propan-2-ol; 2-propanol, 1-(butylamino)-3-phenoxy-; N-(3-Phenoxy-2-hydroxypropyl)butylamine; N-(3-Phenoxy-2-hydroxypropyl)-butylamine
• CAS NO: 29638-63-9
• Molecular Formula: C₁₃H₂₁NO₂
• Molecular Weight: 223.3113
• Mol File: 29638-63-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 362.1°C at 760 mmHg
• Flash Point: 172.8°C
• Density: 1.018g/cm³
• Vapor Pressure: 7.06E-06mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 1-(butylamino)-3-phenoxypropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(butylamino)-3-phenoxypropan-2-ol(29638-63-9)
• EPA Substance Registry System: 1-(butylamino)-3-phenoxypropan-2-ol(29638-63-9)

Safety Data

• Hazardous Substances Data: 29638-63-9(Hazardous Substances Data)

Upstream product

• 122-60-1 Phenyl glycidyl ether 
• 109-73-9 N-butylamine 
• 75-61-6 dibromodifluoromethane 
• 192652-08-7 C₂₂H₂₂O₃ 
• 122-99-6 2-Phenoxyethanol 
• 108-95-2 phenol 
• 2120-70-9 2-phenoxyethanal 

Relevant articles and documents

Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols

An efficient synthesis of β-amino alcohols from a variety of epoxides and primary unbranched amines in the absence of any catalyst in high yields and regioselectivities is reported. A variety of polar mixed solvent systems allow for the selective formation of secondary amino alcohols over tertiary amino alcohols. The reaction scope extends to a wide variety of aromatic and aliphatic substituted epoxides and primary amines bearing complex functionality.

Corrigendum to "Regioselective ring-opening of epoxides with amines using Zn(ClO4)2-Al2O3 as a heterogeneous and recyclable catalyst". [Tetrahedron Lett. 49 (2008) 1795] (DOI:10.1016/j.tetlet.2008.01.044)

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A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium

Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LTV (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethane are the best dihalocarbene precursors. The yields obtained using halofluromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer may be proposed.