29640-90-2Relevant articles and documents
MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut
Yan, Jingjing,MacDonald, John C.,Maag, Alex R.,Coudert, Fran?ois-Xavier,Burdette, Shawn C.
, p. 8393 - 8400 (2019/05/28)
Photoswitchable components can modulate the properties of metal organic frameworks (MOFs); however, photolabile building blocks remain underexplored. A new strut NPDAC (2-nitro-1,4-phenylenediacetic acid) that undergoes photodecarboxylation has been prepared and incorporated into a MOF, using post-synthetic linker exchange (PSLE) from the structural analogue containing PDAC (p-phenylenediacetic acid). Irradiation of NPDAC-MOF leads to MOF decomposition and concomitant formation of amorphous material. In addition to complete linker exchange, MOFs containing a mixture of PDAC and NPDAC can be obtained through partial linker exchange. In NPDAC30-MOF, which contains approximately 30 % NPDAC, the MOF retains crystallinity after irradiation, but the MOF contains defect sites consistent with loss of decarboxylated NPDAC linkers. The defect sites can be repaired by exposure to additional PDAC or NPDAC linkers at a much faster rate than the initial exchange process. The photoremoval and replacement process may lead to a more general approach to customizable MOF structures.
8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity
Singer, Jamie M.,Barr, Bridget M.,Coughenour, Linda L.,Gregory, Tracy F.,Walters, Michael A.
, p. 4560 - 4563 (2007/10/03)
Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia.