2965-17-5

Basic information

• Product Name: (2-fluorophenoxy)acetyl chloride
• Synonyms: (2-fluorophenoxy)acetyl chloride;acetyl chloride, (2-fluorophenoxy)-;2-(2-fluorophenoxy)acetyl chloride;2-(2-fluorophenoxy)ethanoyl chloride
• CAS NO: 2965-17-5
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.5834432
• Mol File: 2965-17-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 140-140.5 °C
• Boiling Point: 150-155 °C(Press: 70-75 Torr)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2-fluorophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-fluorophenoxy)acetyl chloride(2965-17-5)
• EPA Substance Registry System: (2-fluorophenoxy)acetyl chloride(2965-17-5)

Safety Data

• Hazardous Substances Data: 2965-17-5(Hazardous Substances Data)

Usage

Description

(2-fluorophenoxy)acetyl chloride is a chemical compound consisting of a benzene ring with a fluorine atom and an acetyl chloride group attached. It is a colorless, volatile liquid with a pungent odor.

Uses

Used in Pharmaceutical Industry:
(2-fluorophenoxy)acetyl chloride is used as an intermediate for the synthesis of various pharmaceuticals due to its reactive nature, which allows for the creation of a wide range of medicinal compounds.
Used in Pesticide Industry:
(2-fluorophenoxy)acetyl chloride is used as a chemical intermediate in the production of pesticides, contributing to the development of effective crop protection agents.
Used in Organic Compounds Synthesis:
(2-fluorophenoxy)acetyl chloride is utilized as a building block in the synthesis of various organic compounds, owing to its ability to readily participate in chemical reactions.
Precautions:
Due to its reactivity and potential health hazards, (2-fluorophenoxy)acetyl chloride should be handled with care. It is important to store and use it in a well-ventilated area and with appropriate safety equipment to prevent harm to human health and the environment.

Upstream product

• 348-10-7 (2-fluorophenoxy)acetic acid 
• 367-12-4 2-fluorophenol 
• 2248-56-8 ethyl 2-(4-fluorophenoxy)acetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1031434-74-8 C₂₃H₁₉FN₂O₃ 
• 904702-63-2 C₁₆H₁₇FNO₅P 
• 866146-00-1 O,O-dimethyl α-(2-fluorophenoxyacetoxy)ethylphosphonate 
• 1395103-23-7 2-[(2-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-28-2 2-(2-fluorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 904702-68-7 O-methyl [(2-(2-fluorophenoxy)acetoxy)(2-chlorophenyl)methyl]methylphosphinate 
• 904702-69-8 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-fluorophenyl)methyl]methylphosphinate 

Relevant articles and documents

Herbicidal activity and application cyclic of phosphonates

Among alkylphosphonates Io,O,O-dimethyl 1-(2,4-dichlorophenoxyacetoxy) ethylphosphonate (clacyfos) was found to be an effective inhibitor against dicotyledons PHDc and exhibited excellent herbicidal activity in our previous work. According to our study on the alkylphosphonates Io, both R1 and R2 groups in the structural unit of phosphorus-containing played a very important role in herbicidal activity. Therefore, a series of 2-[1-(substituted phenoxycarboxy)alkyl]-5,5-dimethyl-1,3,2-dioxaphosphinane-2-one containing fluorine II was obtained by the modification of alkylphosphonates Io. The bioassay results showed that cyclic phosphonate II-6 with CH3 as R, 2-Cl,4-F as Yn exhibited promising herbicidal activity. Its herbicidal activity, weed-controlling spectrum, selectivity between crops and weeds were further evaluated in greenhouse and field.

Privileged 1,2,4-oxadiazoles in anticancer drug design: Novel 5-aryloxymethyl-1,2,4-oxadiazole leads for prostate cancer therapy

Based on the structure of the previously identified leads, new series of compounds containing 1,2,4-oxadiazole core was designed. A small, diverse library of 51 compounds including both 2-(acylamino)ethyl and 2-ureidoethyl side chains was synthesized using parallel chemistry and tested for antiproliferative activity against prostate cancer DU-145 cell line. Four hit compounds - all belonging to 2-ureidoethyl series - were identified and three compounds were confirmed as 10-20 μM inhibitors. The similarity in compounds' periphery and the data obtained previously suggest a similar mode of action for these compounds which was postulated as tubulin inhibition and was confirmed by in silico docking. These data provide further evidence for the privileged character of 1,2,4-oxadiazoles in antiproliferative compound design.

Synthesis and Herbicidal Activities of Sodium Methyl(α-(Substituted Phenoxyacetoxy)Alkyl)Phosphinates

A series of sodium methyl(α-(substituted phenoxyacetoxy)alkyl)phosphinates was designed and synthesized. Their structures were confirmed by IR, 1H NMR and elemental analysis, and some of them were further confirmed by MS. The results of bioassay showed that most of title compounds exhibited moderate to good herbicidal activities against the root of barnyard grass and rape at 10～100 mg/L.