296759-67-6

Basic information

• Product Name: 1-(4-fluorophenyl)-5-phenyl-2,4-pentadien-1-one
• Synonyms: 1-(4-fluorophenyl)-5-phenyl-2,4-pentadien-1-one
• CAS NO: 296759-67-6
• Molecular Formula: C₁₇H₁₃FO
• Molecular Weight: 252.2829232
• Mol File: 296759-67-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-fluorophenyl)-5-phenyl-2,4-pentadien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-5-phenyl-2,4-pentadien-1-one(296759-67-6)
• EPA Substance Registry System: 1-(4-fluorophenyl)-5-phenyl-2,4-pentadien-1-one(296759-67-6)

Safety Data

• Hazardous Substances Data: 296759-67-6(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 296759-74-5 3-(4-fluorobenzoyl)-4-styryl-2-pyrazoline 
• 1239465-62-3 (R,E)-1-(4-fluorophenyl)-3-(nitromethyl)-5-phenylpent-4-en-1-one 
• 1239279-04-9 (S,E)-2-[1-(4-fluorophenyl)-1-oxo-5-phenylpent-4-en-3-yl]malononitrile 
• 1354729-18-2 C₂₄H₂₃FO 

Relevant articles and documents

Palladium-Catalyzed Aminomethylation of Nitrodienes and Dienones via Double C—N Bond Activation

A new strategy for the generation of the active Pd-alkyl species from aminal via C—N bond activation has been established, in which the formation of zwitterionic intermediate through aza-Michael addition of aminal to nitrodienes or dienones is identified as a key step for the activation of the C—N bond. The efficient strategy has enabled a new palladium-catalyzed α-aminomethylation of nitrodienes and dienones via double C—N bond activation. The scope and versatility of the reaction were demonstrated and a broad range of substrates bearing electron-donating and -withdrawing groups on the aromatic rings were all compatible with this reaction to furnish the desired α-aminomethylated products in moderate to good yields with excellent regioselectivities and E/Z selectivities.

Highly regioselective introduction of aryl substituents via asymmetric 1,4-addition of boronic acids to linear α,β,γ,δ-unsaturated ketones

An efficient palladium(II)-catalyzed regioselective asymmetric 1,4-conjugate addition of arylboronic acids to linear α,β,γ,δ-unsaturated ketones is developed using phosphapalladacycle catalysts. The relevant 1,4-products were obtained exclusively with per

Synthesis, antimicrobial and cytotoxic activity of novel 1,5 benzodiazepine derivatives

In the present study, a series of novel 2-(substituted phenyl)-3-styryl-2,3-dihydro- 1H-benzo [b] [1,4] diazepines (1-12) has been synthesized from 1,5-(disubstituted phenyl)-2,4-pentadien-1-ones (1a-12a). 1,5-(disubstituted phenyl)-2,4-pentadien-1-ones were prepared by condensing cinnamaldehyde with various aromatic ketones in the presence of 20% NaOH as base. Different 1,5-(disubstituted phenyl)-2,4-pentadien-1-ones on cyclisation with o-phenylene diamine in the presence of NaOH as base resulted in 2-(substituted phenyl)-3-styryl-2,3-dihydro-1H-benzo [b] [1,4] diazepine derivatives. The structures of the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies. All titled compounds were screened for their antimicrobial and cytotoxic activities. Most of the compounds showed promising cytotoxic, antibacterial and antifungal activities.