2968-33-4

Basic information

• Product Name: 3,3,3-TRIFLUOROPROPYLAMINE HYDROCHLORIDE
• Synonyms: 3,3,3-Trifluoropropan-1-amine hydrochloride;3,3,3-TrifluoropropylaMine Monohydrochloride;1-PropanaMine, 3,3,3-trifluoro-, hydrochloride;3-Amino-1,1,1-trifluoropropane hydrochloride;3,3,3-Trifluoro-1-propanamine hydrochloride;2-TRIFLUOROMETHYL-ETHYLAMINE HYDROCHLORIDE;3,3,3-TRIFLUORO-N-PROPYLAMINE HYDROCHLORIDE;3,3,3-TRIFLUOROPROPYLAMINE HCL
• CAS NO: 2968-33-4
• Molecular Formula: C₃H₆F₃N*ClH
• Molecular Weight: 149.54
• Mol File: 2968-33-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 222-223
• Boiling Point: 30.6 °C at 760 mmHg
• Flash Point: 8.7 °C
• Appearance: /
• Density: 5.2
• Vapor Pressure: 616mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3,3,3-TRIFLUOROPROPYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-TRIFLUOROPROPYLAMINE HYDROCHLORIDE(2968-33-4)
• EPA Substance Registry System: 3,3,3-TRIFLUOROPROPYLAMINE HYDROCHLORIDE(2968-33-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-52-41-37/38-22
• Safety Statements: 36/37/39-39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 2968-33-4(Hazardous Substances Data)

Usage

General Description

3,3,3-Trifluoropropylamine hydrochloride is a chemical compound with the molecular formula C3H8F3NCl. It is a colorless to pale yellow liquid that is used in various pharmaceutical and chemical synthesis processes. It is a highly reactive compound, and is primarily used as a reagent in the production of various pharmaceuticals, agrochemicals, and specialty chemicals. It is also used as a building block in the synthesis of various organic compounds, including fluorinated compounds, which are widely utilized in the pharmaceutical and agrochemical industries. Additionally, it has applications in the production of surfactants and other specialty chemicals. Overall, 3,3,3-Trifluoropropylamine hydrochloride is a versatile chemical that has a wide range of applications in the pharmaceutical, agrochemical, and specialty chemical industries.

InChI:InChI=1/C3H6F3N.ClH/c4-3(5,6)1-2-7;/h1-2,7H2;1H

Upstream product

• 347190-33-4 2-(3,3,3-trifluoropropyl)isoindoline-1,3-dione 

Downstream Products

• 1275727-03-1 4-iodo-N-(3,3,3-trifluoropropyl)benzamide 
• 1589818-99-4 4-acetyl-N-(3,3,3-trifluoropropyl)benzamide 
• 1589818-98-3 4-(2-methylthiazol-4-yl)-N-(3,3,3-trifluoropropyl)benzamide 
• 1455038-18-2 1-(5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)-3-(3,3,3-trifluoropropyl)urea 
• 1256969-32-0 C₁₆H₁₁ClF₃N₃O₃ 
• 1236403-98-7 N-(8-methyl-3-{[(3,3,3-tritluoropropyl)amino]methyl}quinolin-7-yl)-4-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide 

Relevant articles and documents

Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia

[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide ([18F]-EF3) has been prepared, in 65% chemical yield and 5% radiochemical yield, by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate 1 with [18F]-3,3,3-trifluoropropylamine 7. This original radiolabelled key-synthon was obtained in 40% overall chemical yield by oxidative [18F]-fluorodesulfurization of ethyl N-phthalimido-3-aminopropane dithioate 4, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine 5. All the process was performed within 90min, from the [18F]-HF production in the cyclotron to the purification of the final target. Copyright