29682-39-1

Basic information

• Product Name: 1-BROMO-2-CHLORO-4-NITROBENZENE
• Synonyms: 1-BROMO-2-CHLORO-4-NITROBENZENE;4-Bromo-3-chloronitrobenzene;2-Chloro-4-nitro-1-bromobenzene;2-chloro-4-nitrobroMobenzene;3-chloro-4-broMonitrobenzene;Benzene, 1-broMo-2-chloro-4-nitro-
• CAS NO: 29682-39-1
• Molecular Formula: C₆H₃BrClNO₂
• Molecular Weight: 236.45
• EINECS: 249-773-8
• Mol File: 29682-39-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 59-62°C
• Boiling Point: 282.2 °C at 760 mmHg
• Flash Point: 124.5 °C
• Appearance: /
• Density: 1.827 g/cm³
• Vapor Pressure: 0.0058mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2253107
• CAS DataBase Reference: 1-BROMO-2-CHLORO-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-CHLORO-4-NITROBENZENE(29682-39-1)
• EPA Substance Registry System: 1-BROMO-2-CHLORO-4-NITROBENZENE(29682-39-1)

Safety Data

• Statements: 20/21/22-33-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 29682-39-1(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-chloro-4-nitrobenzene is a synthetic, organic chemical compound, also termed as 1-bromo-2-chloro-4-nitrobenzene. It has a molecular structure comprising of a benzene ring bound with a bromine (Br), chlorine (Cl), and a nitro group (NO2). This chemical possesses an aromatic structure which gives it a stable nature. It has the molecular formula C6H3BrClNO2 and comes under the class of organobromides and organochlorides. It is generally used as a building block in organic synthesis and it’s an important intermediate in the manufacture of other compounds in the pharmaceutical and chemical industries. Suitable precautions should be taken while handling it as it may cause skin and eye irritation and may be harmful if swallowed or inhaled.

InChI:InChI=1/C6H3BrClNO2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H

Upstream product

• 121-87-9 2-Chloro-4-nitroaniline 
• 694-80-4 2-bromo-1-chlorobenzene 
• 7697-37-2 nitric acid 
• 401631-87-6 C₁₀H₁₃ClN₄O₂ 
• 99-54-7 3,4-dichloronitrobenzene 

Downstream Products

• 21402-26-6 4-bromo-3-chloroaniline 
• 15426-14-9 3,3'-dichloroazobenzene 
• 347190-79-8 2,5-bis(2-chloro-4-nitrophenyl)furan 
• 678970-22-4 2-chloro-1-(1-ethoxy-vinyl)-4-nitro-benzene 
• 13382-62-2 4-(2-chloro-4-nitro-phenyl)-oxazole 
• 87154-68-5 3-chloro-4-(bromoacetyl)nitrobenzene 
• 50638-46-5 4-bromo-3-chloroanisole 
• 13631-21-5 4-bromo-3-chlorophenol 
• 36776-29-1 2-chloro-4-nitro-thiophenol 
• 130546-37-1 (2-Chloro-4-nitrophenoxy)ethylene 
• 689300-56-9 3-(2-chloro-4-nitro-phenyl)-prop-2-yn-1-ol 
• 62322-92-3 1-(2'-chloro-4'-nitroanilino)-5-methoxyanthraquinone 
• 4420-82-0 2-(2-chloro-4-nitrophenyl)pyridine 
• 1173174-00-9 C₁₄H₁₈ClN₃O₄ 

Relevant articles and documents

BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME

The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease.

1-Aryl-3,3-dialkyltriazenes: A convenient synthesis from dry arenediazonium o-benzenedisulfonimides - A high yield break down to the starting dry salts and efficient conversions to aryl iodides, bromides and chlorides

This research comprises three parts. The first part regards the synthesis of 1-aryl-3,3-dialkyltriazenes 3 by reaction of dry arenediazonium o-benzenedisulfonimides 1, also coming from weakly basic aromatic amines with dimethylamine or diethylamine in aqueous solution at 0-5 °C. Yields were usually greater than 90% and there was the possibility of recovering the o-benzenedisulfonimide (5), which could be reused to prepare the salts 1. In the second part it was demonstrated that there is the possibility of reconverting the triazenes 3 into the starting stable dry salts 1 by using 5 as acid. The reactions were carried out in glacial acetic acid at 50-55 °C and normally afforded salts 1 in yields of around 90-99%. The third part concerns the setting up of two procedures for the conversion of 3 to aryl iodides 9, bromides 10 and chlorides 11. Procedure A used the corresponding aqueous hydrogen halides in acetonitrile at r.t. or 60 °C, sometimes in the presence of aqueous HBF4, sometimes Cu powder (25 examples, yields 65%-88%). Procedure B usually used anhydrous methanesulfonic acid and tetraalkylammonium halides in anhydrous acetonitrile at temperatures varying from r.t. to 80 °C, sometimes in the presence of Cu (16 examples, yields 65-88%).