29702-43-0 Usage
Description
2-Deoxy-2-fluoro-D-glucose (2DFG) is a synthetic glucose analog that differs from natural glucose by the replacement of a hydroxyl group with a fluorine atom at the 2nd carbon position. It is a white solid and is known to act as a substrate for hexokinase isozymes, which are key enzymes involved in glucose metabolism.
Uses
Used in Pharmaceutical Industry:
2-Deoxy-2-fluoro-D-glucose is used as a pharmaceutical agent for targeting cancer cells. It works by inhibiting hexokinase enzymes, which are overexpressed in rapidly proliferating cancer cells, thus disrupting their energy production and leading to cell death. Its application in cancer therapy is due to its ability to preferentially affect cancer cells while sparing normal cells.
Used in Research and Development:
In the field of research, 2-Deoxy-2-fluoro-D-glucose is used as a tool to study the role of glucose metabolism in various biological processes. It helps researchers understand the mechanisms of glucose uptake and utilization in cells, as well as the impact of altered glucose metabolism on cellular functions and disease progression.
Used in Drug Delivery Systems:
Similar to gallotannin, 2-Deoxy-2-fluoro-D-glucose can also be incorporated into drug delivery systems to improve its bioavailability and therapeutic efficacy. These systems can be designed to specifically target cancer cells, enhancing the drug's effectiveness and reducing potential side effects on healthy tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 29702-43-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,7,0 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 29702-43:
(7*2)+(6*9)+(5*7)+(4*0)+(3*2)+(2*4)+(1*3)=120
120 % 10 = 0
So 29702-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2
29702-43-0Relevant articles and documents
Fluoro-substituted epipodophyllotoxin glucosides
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, (2008/06/13)
The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.
