298-36-2 Usage
Description
5α-Pregnan-21-ol-3,20-dione crystalline, also known as 5α-Dihydrodeoxycorticosterone, is a steroidal compound derived from the pregnane family. It is characterized by its unique molecular structure, featuring a 21-ol group and a 3,20-dione group. 5A-PREGNAN-21-OL-3-20-DIONE CRYSTALLINE has been found to have significant biological activities, particularly in the context of cancer cell proliferation.
Uses
Used in Pharmaceutical Industry:
5α-Pregnan-21-ol-3,20-dione crystalline is used as a research compound for understanding its role in promoting prostate cancer cell proliferation through androgen receptor (AR) activation. This application is crucial for the development of targeted therapies and potential treatments for prostate cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 298-36-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 298-36:
(5*2)+(4*9)+(3*8)+(2*3)+(1*6)=82
82 % 10 = 2
So 298-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15-,16-,17-,18+,20-,21-/m0/s1
298-36-2Relevant articles and documents
Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436
Holland, Herbert L.
, p. 646 - 649 (2007/10/02)
The biotransformation of a series of corticosteroids by the fungus Penicillium decumbens ATCC 10436 has been investigated. Conversion to the corresponding 5α-dihydroxteroid was observed for all the Δ4-3-ketosteroids studied with the exception of deoxycorticosterone, which was converted to a Δ14-diene. Deoxycorticosterone acetate was, however, converted to a 5α- dihydro product concomitant with ester hydrolysis. Other substrates carrying a C-21 acetoxy group were also hydrolyzed to the alcohol. In two cases (resulting from deoxycorticosterone acetate and 11-deoxycortisone) the 5α- 3-keto-product was further reduced to the 3β-alcohol. No reduction of δ14-dienes was observed.