29817-35-4Relevant articles and documents
Condon
, p. 3608,3609-3615 (1972)
A Four-Component Reaction for the Synthesis of Dioxadiazaborocines
Flagstad, Thomas,Petersen, Mette T.,Nielsen, Thomas E.
supporting information, p. 8395 - 8397 (2015/11/27)
A four-component reaction for the synthesis of heterocyclic boronates is reported. Readily available hydrazides, α-hydroxy aldehydes, and two orthogonally reactive boronic acids are combined in a single step to give structurally distinct bicyclic boronates, termed dioxadiazaborocines (DODA borocines). In this remarkable process, one boronic acid reacts as a carbon nucleophile and the other as a boron electrophile to provide enantio- and diastereomerically pure heterocyclic boronates with multiple stereocenters in high yields.