298198-53-5

Basic information

• Product Name: 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid p-tolyl ester
• CAS NO: 298198-53-5
• Molecular Weight: 260.336
• Mol File: 298198-53-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid p-tolyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid p-tolyl ester(298198-53-5)
• EPA Substance Registry System: 1,4-diaza-bicyclo[3.2.2]nonane-4-carboxylic acid p-tolyl ester(298198-53-5)

Safety Data

• Hazardous Substances Data: 298198-53-5(Hazardous Substances Data)

Upstream product

• 283-38-5 1,4-diazabicyclo[3.2.2]nonane 
• 937-62-2 p-tolyl chloroformate 

Relevant articles and documents

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates - subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of α7 nAChR agonists is described. The development of the medicinal chemistry strategy and SAR which led to the identification of 5 and 7aa as subtype selective, high affinity α7 agonists as excellent leads for further evaluation is discussed, along with key physicochemical and pharmacokinetic data highlighting their lead potential.

Pharmaceutical compositions for the treatment of disorders of the CNS and other disorders

The present invention relates to a method of treating disorders of the central nervous system (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.