298204-37-2

Basic information

• Product Name: Cyclohexanecarboxylic acid, 2-amino-4-hydroxy-, (1S,2R,4S)- (9CI)
• Synonyms: Cyclohexanecarboxylic acid, 2-amino-4-hydroxy-, (1S,2R,4S)- (9CI)
• CAS NO: 298204-37-2
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.18302
• Product Categories: CARBOXYLICACID
• Mol File: 298204-37-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexanecarboxylic acid, 2-amino-4-hydroxy-, (1S,2R,4S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 2-amino-4-hydroxy-, (1S,2R,4S)- (9CI)(298204-37-2)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 2-amino-4-hydroxy-, (1S,2R,4S)- (9CI)(298204-37-2)

Safety Data

• Hazardous Substances Data: 298204-37-2(Hazardous Substances Data)

Upstream product

• 865689-33-4 ethyl (1S,2R)-2-acetylamino-4-cyclohexanecarboxylate 
• 57266-61-2 ethyl cis-2-amino-4-cyclohexene-1-carboxylate hydrochloride 
• 57266-61-2 ethyl trans-2-amino-4-cyclohexanecarboxylate hydrochloride 
• 1177193-29-1 C₁₅H₁₉NO₅ 

Relevant articles and documents

Stereoselective synthesis of hydroxylated β-aminocyclohexanecarboxylic acids

A simple synthetic approach has been developed for the regio- and diastereoselective synthesis of hydroxylated 2-aminocyclohexanecarboxylic acid stereoisomers from 1,4-cyclohexadiene by the reductive opening of appropriate epoxide intermediates derived from the corresponding bicyclic β-lactams. This method has been extended to the synthesis of these hydroxylated β-amino acids in enantiomerically pure form.

Synthesis of 3- and 4-hydroxy-2-aminocyclohexanecarboxylic acids by lodocyclization

Starting from cis-7-azabicyclo[4.2.0]oct-4-en-8-one, novel routes have been developed for the synthesis of 2-amino-4-hydroxycyclohexanecarboxylic acid and its 3-hydroxy-substituted analog via iodooxazine, iodooxazoline or iodolactone intermediates. After CAL-B-catalyzed enzymatic transformation of the starting β-lactam, the iodolactone method was applied to the synthesis of 3-hydroxy-substituted β-amino acid enantiomers. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.