298691-10-8Relevant articles and documents
The design and synthesis of a 5-HETE affinity chromatography ligand for 5-hydroxyeicosanoid dehydrogenase
Khanapure, Subhash P.,Saha, Goutam,Powell, William S.,Rokach, Joshua
, p. 5807 - 5811 (2007/10/03)
The first total synthesis of an ω-amino 5-HETE derivative 27 has been accomplished by a new counter-clockwise strategy, in which C-1 is constructed first and C-20 last. The ω-amino 5-HETE derivative was transformed to an affinity chromatography ligand, the biotinylated 5-HETE 30. This affinity chromatography ligand is aimed at purifying the 5-hydroxyeicosanoid dehydrogenase enzyme, which is responsible for the conversion of 5-HETE to 5- oxo-ETE, a potent eosinophil chemotactic factor. (C) 2000 Elsevier Science Ltd.
