298699-25-9

Basic information

• Product Name: 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione
• CAS NO: 298699-25-9
• Molecular Weight: 433.334
• Mol File: 298699-25-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione(298699-25-9)
• EPA Substance Registry System: 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione(298699-25-9)

Safety Data

• Hazardous Substances Data: 298699-25-9(Hazardous Substances Data)

Upstream product

• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 

Relevant articles and documents

Compounds

The invention provides compounds of general formula (I) wherein: R1represents optionally substituted, C1-C12alkyl or optionally substituted 3- to 10-membered saturated or unsaturated ring system comprising up to two ring carbon atoms that form carbonyl groups and comprising up to 4 ring heteroatoms independently selected from nitrogen, oxygen and sulfur; m is 0-1; Q represents OCH2, C1-C4alkylene or C2-C4alkenylene; T represents C(O)NH, or when m is 0, T may additionally represent a bond or NH, or when m is 1 and Q represents C1-C4alkylene, T may additionally represent NH; n is 1-4; each R2and R3independently represents H or C1-C4alkyl; V represents N, and W represents N or CH; X represents O, C(O), CH(OH), SO2, NH or N(C1-C6alkyl), provided that when W represents N, then X represents either C(O) or SO2and when W represents CH, then X is other than SO2; R4represents optionally substituted phenyl; R5and R6each independently represent H, C1-C6alkyl or hydroxyC1-C6alkyl, or R5and R6together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring; R7and R8each independently represent H or C1-C6alkyl; and R9represents OH or —NR7R8; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.