29880-63-5

Basic information

• Product Name: 1-(5-tert-butylthiophen-2-yl)ethanone
• CAS NO: 29880-63-5
• Molecular Formula: C₁₀H₁₄OS
• Molecular Weight: 182.2826
• Mol File: 29880-63-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 249.5°C at 760 mmHg
• Flash Point: 104.7°C
• Density: 1.029g/cm³
• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 1-(5-tert-butylthiophen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-tert-butylthiophen-2-yl)ethanone(29880-63-5)
• EPA Substance Registry System: 1-(5-tert-butylthiophen-2-yl)ethanone(29880-63-5)

Safety Data

• Hazardous Substances Data: 29880-63-5(Hazardous Substances Data)

Usage

Physical state

Pale yellow liquid

Odor

Strong

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Chemical structure

Thiophene ring substituted with a tert-butyl group and an ethanone group

Safety precautions

Handle with caution, may cause irritation to skin, eyes, and respiratory system

Storage and usage

Store and use in a well-ventilated area

Upstream product

• 1689-78-7 2-tert-butylthiophene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 88-15-3 2-Acetylthiophene 
• 38442-51-2 tert-butylmercury chloride 
• 5370-25-2 2-Acetyl-5-bromothiophene 

Downstream Products

• 29212-25-7 5-(tert-butyl)thiophene-2-carboxylic acid 
• 832113-93-6 5-tert-butyl-2-thiophenecarboxylic acid chloride 
• 685120-65-4 5-tert-butyl-thiophene-2-carboxylic acid amide 
• 15898-92-7 6,6-Dimethyloenanthsaeure 
• 102600-80-6 (+/-)-1-(5-tert-butyl-[2]thienyl)-3ξ-(2,6,6-trimethyl-cyclohex-2-enyl)-propenone 

Relevant articles and documents

Acid- or base-promoted photostimulated homolytic tert-butylation of pyridines and thiophenes

Regioselective photostimulated homolytic tert-butylations for heteroaromatics such as pyridines or thiophenes are investigated with tert-butylmercury(II) chloride in the presence of toluene-p-sulfonic acid (PTSA) or 1,4-diaza-bicyclo[2.2.2]octane (DABCO)

SYNTHESIS AND ELECTROPHILIC TRICHLOROMETHYLATION OF 2,4-DIALKYLTHIOPHENES. SOME TRANSFORMATIONS OF 2,4-DI-tert-BUTYL-5-(TRICHLOROMETHYL)THIOPHENE

The disproportionation products of the C-protonation of 5-tert-butyl-2-methyl- and 2-ethylthiophene first give 4-tert-butyl-2-methyl- and 2-ethylthiophene. We studied the electrophilic trichloromethylation of a series of 2,4-dialkyl thiophenes and showed that the reaction goes smoothly only for the most sterically hindered 2,4-di-tert-butyl-thiophene. We studied the reaction of 2,4-di-tert-butyl-5-(trichloromethyl)thiophene with some O- and N-nucleophiles.