29938-41-8

Basic information

• Product Name: Thietane, 2-phenyl-
• CAS NO: 29938-41-8
• Molecular Formula: C9H10S
• Molecular Weight: 150.244
• Mol File: 29938-41-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thietane, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thietane, 2-phenyl-(29938-41-8)
• EPA Substance Registry System: Thietane, 2-phenyl-(29938-41-8)

Safety Data

• Hazardous Substances Data: 29938-41-8(Hazardous Substances Data)

Upstream product

• 17714-42-0 1,3-dibromo-1-phenylpropane 
• 14155-36-3 (+/-)-(1,3-dichloropropyl)benzene 
• 936-59-4 3-chloropropiophenone 
• 55955-55-0 methyl 3-chloro-3-phenylpropyl ether 
• 100-42-5 styrene 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 

Downstream Products

• 67966-89-6 2-phenylthiaetane-S,S-dioxide 
• 190205-97-1 3-ethyl-6-mercapto-4-phenyl-3-hexanol 
• 190205-98-2 1-(3-mercapto-1-phenylpropyl)-1-cyclopentanol 

Relevant articles and documents

Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides

Starting from readily available C2-substituted thietane 1-oxides, a straightforward synthesis of new C2,C4-disubstituted thietane 1-oxides has been developed by using a lithiation/electrophilic trapping sequence. The chemical and configurational stability of lithiated C2-substituted thietane 1-oxides has been investigated as well as the stereochemical implications for this process. The results demonstrate that a stereoselective functionalization at the C2, C4 positions of a thietane is feasible, leaving intact the four-membered ring.

Synthesis of 2-alkyl(aryl)thietanes

Thietane and its 2-substituted derivatives were synthesized. A general preparation procedure for the synthesis of thietanes bearing alkyl and aryl substituents in the α-position was developed. Using this procedure, 2-substituted thietanes can be obtained from cheap and easily accessible raw materials in three steps. 2-R-Thietanes (where R = H, CH3, C 4H9, C5H11, C6H 13, C6H5) and the corresponding sulfoxides and sulfones were synthesized and examined. Intermediate and by-products of the synthesis were studied. Nauka/Interperiodica 2007.

Reductive opening of phenyl substituted thiacycloalkanes: New way for sulphur-containing organolithium compounds

The reaction of 2-phenyl substituted four, five and six membered thiacycloalkanes (1, 4 and 7) with lithium and a catalytic amount of DTBB (5 mol %) in THF at -78°C leads to the corresponding sulphur-containing benzylic organolithium compounds (2, 5 and 8), which by reaction with different electrophiles [D2O, Me3SiCl, Bu(t)CHO, Me2CO, Et2CO, (CH2)4CO, CO2] followed by hydrolysis with water afford the expected functionalised mercaptans (3, 6 and 9) in a regioselective manner. Some reaction products (3, 6) are cyclised under acidic conditions (85% phosphoric acid) to yield the corresponding homologous substituted sulphur-containing saturated heterocycles (10, 11).