29968-78-3 Usage
Description
4-Nitrophenethylamine hydrochloride is a chemical compound that exists as a yellow to brown crystalline powder and chunks. It is an organic compound derived from phenethylamine, featuring a nitro group at the para position and a hydrochloride group attached, which contributes to its unique chemical properties and potential applications.
Uses
Used in Chemical Synthesis:
4-Nitrophenethylamine hydrochloride is used as a synthetic intermediate for the production of ortho-metalated primary phenethylamines complexes containing six-membered palladacycles and N-(4-nitrophenethyl)formamide. These complexes have potential applications in various fields, including catalysis and pharmaceuticals, due to their unique structural and electronic properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Nitrophenethylamine hydrochloride serves as a key building block for the synthesis of various active pharmaceutical ingredients. Its reactivity and functional groups make it a versatile compound for the development of new drugs with potential therapeutic applications.
Used in Research and Development:
4-Nitrophenethylamine hydrochloride is also utilized in research and development settings, where it can be employed to study the properties and reactivity of related compounds. Its use in this context aids in the advancement of scientific knowledge and the discovery of new chemical processes and applications.
Used in Analytical Chemistry:
As a compound with distinct chemical properties, 4-Nitrophenethylamine hydrochloride can be used in analytical chemistry for the detection and quantification of specific substances. Its characteristic color and reactivity make it a valuable tool for various analytical techniques, such as spectroscopy and chromatography.
Preparation
The preparation of 4-Nitrophenethylamine hydrochloride is as follows:Ten mL of 2M HCl was then added in a one-pot fashion, and, in all cases but threonine, the reaction vessel was heated to 190°Cover 5 min with stirring and then allowed to cool. In the case of the temperature-sensitive threonine, soxhlet extraction with toluene was performed at 80°C to remove R-carvone from the reaction mixture. The aqueous reaction mixture was washed three times with 25 mL of ether, and then water solvent was distilled off from the hydrochloride salt. The hydrochloride salt was transferred to a vacuum oven and dried overnight at 150 °C and 10 Torr.
Check Digit Verification of cas no
The CAS Registry Mumber 29968-78-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,9,6 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 29968-78:
(7*2)+(6*9)+(5*9)+(4*6)+(3*8)+(2*7)+(1*8)=183
183 % 10 = 3
So 29968-78-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2/c9-6-5-7-1-3-8(4-2-7)10(11)12/h1-4H,5-6,9H2/p+1
29968-78-3Relevant articles and documents
Catalytic Staudinger Reduction at Room Temperature
Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin
, p. 6536 - 6545 (2019/05/24)
We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
Production preparation method of p-nitrophenylethylamine hydrochloride
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Paragraph 0060; 0066; 0071, (2018/03/23)
The invention provides a production preparation method of p-nitrophenylethylamine hydrochloride, belongs to the technical field of drug synthesis, and solves the problems that in the prior art the synthetic p-nitrophenylethylamine hydrochloride is low in conversion rate of and is not suitable for large-scale industrial production. Synthesis steps include 1) amino protection, to be more specific, using beta-phenylethylamine as a raw material for reacting with an acyl protecting agent in a solvent to obtain an intermediate 1; 2) nitrating reaction, to be more specific, adding dropwise the intermediate 1 prepared by the step 1) into concentrated sulfuric acid, maintaining reaction temperature at room temperature, slowly adding dropwise concentrated nitric acid, after the completion of the reaction, adding crushed ice, adding an alkaline solution to adjust the pH to alkaline, and filtering to obtain an intermediate 2; and 3) deprotection, to be more specific, adding dropwise hydrochloric acid into the intermediate 2 in a solvent to adjust the pH to acid, heating to reflux, cooling, and precipitating the product p-nitrophenylethylamine hydrochloride. The production preparation method ofthe p-nitrophenylethylamine hydrochloride has low cost and high product yield, and is suitable for large-scale industrial production.
Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems
Hoefnagel, A. J.,Vos, R. H. de,Wepster, B. M.
, p. 22 - 28 (2007/10/02)
Thermodynamic dissociation constants in various water-organic solvent mixtures are given for benzylammonium, benzyldialkylammonium, and (2-phenylethyl)ammonium ions.Deviations from the Hammett equation (Eqn. 1) are similar to those observed for carboxylic acids, but of opposite sign.The extended Hammett equation (Eqn. 3), containing the hydrophobic constant, ?, yields good correlations.Derived secondary normal sigma values are exemplified.