299956-57-3Relevant articles and documents
Discovery and evolution of aloperine derivatives as novel anti-filovirus agents through targeting entry stage
Zhang, Xin,Liu, Qiang,Zhang, Na,Li, Qian–Qian,Liu, Zhan–Dong,Li, Ying–Hong,Gao, Li–Mei,Wang, You–Chun,Deng, Hong–Bin,Song, Dan–Qing
, p. 45 - 55 (2018)
Preventing filoviruses in the entry stage is an attractive antiviral strategy. Taking aloperine, a Chinese natural herb with an endocyclic skeleton, as the lead, 23 new aloperine derivatives were synthesized and evaluated for their anti-filovirus activiti
Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents
Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.
, p. 1723 - 1727 (2007/10/03)
A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.