30009-05-3

Basic information

• Product Name: trans-N-hydroxy-3-(4-nitro-phenyl)-acrylamide
• Synonyms: trans-N-hydroxy-3-(4-nitro-phenyl)-acrylamide
• CAS NO: 30009-05-3
• Molecular Weight: 208.174
• Mol File: 30009-05-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-N-hydroxy-3-(4-nitro-phenyl)-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-hydroxy-3-(4-nitro-phenyl)-acrylamide(30009-05-3)
• EPA Substance Registry System: trans-N-hydroxy-3-(4-nitro-phenyl)-acrylamide(30009-05-3)

Safety Data

• Hazardous Substances Data: 30009-05-3(Hazardous Substances Data)

Upstream product

• 351027-13-9 N-(p-nitrocinnamoyl)imidazole 
• 882-06-4 4-nitro-trans-cinnamic acid 
• 24393-61-1 ethyl (E)-3-(4-nitrophenyl)-2-propenoate 
• 637-57-0 p-nitrocinnamic acid methyl ester 

Relevant articles and documents

Hydroxamic acids block replication of hepatitis c virus

Intrigued by the role of protein acetylation in hepatitis C virus (HCV) replication, we tested known histone deacetylase (HDAC) inhibitors and a focused library of structurally simple hydroxamic acids for inhibition of a HCV subgenomic replicon. While known HDAC inhibitors with varied inhibitory profiles proved to be either relatively toxic or ineffective, structure-activity relationship (SAR) studies on cinnamic hydroxamic acid and benzo[b]thiophen-2-hydroxamic acid gave rise to compounds 22 and 53, which showed potent and selective anti-HCV activity and therefore are promising starting points for further structural optimization and mechanistic studies.