30034-43-6

Basic information

• Product Name: 7-METHOXY-4-PHENYL-QUINOLIN-2-OL
• Synonyms: 7-methoxy-4-phenyl-2(1H)-Quinolinone
• CAS NO: 30034-43-6
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.2799
• Mol File: 30034-43-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 452.2°Cat760mmHg
• Flash Point: 227.3°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 2.28E-08mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 7-METHOXY-4-PHENYL-QUINOLIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-4-PHENYL-QUINOLIN-2-OL(30034-43-6)
• EPA Substance Registry System: 7-METHOXY-4-PHENYL-QUINOLIN-2-OL(30034-43-6)

Safety Data

• Hazardous Substances Data: 30034-43-6(Hazardous Substances Data)

Usage

General Description

7-METHOXY-4-PHENYL-QUINOLIN-2-OL is a chemical compound with the molecular formula C16H13NO2. It is a quinoline derivative with a methoxy and a phenyl group attached to the 4 and 2 positions of the quinoline ring, respectively. 7-METHOXY-4-PHENYL-QUINOLIN-2-OL is of interest for its potential pharmaceutical and medicinal applications due to its unique structure and potential biological activities. It may have potential as a drug candidate for various therapeutic purposes, and further research is warranted to explore its pharmacological properties and potential uses in medicine.

InChI:InChI=1/C16H13NO2/c1-19-12-7-8-13-14(11-5-3-2-4-6-11)10-16(18)17-15(13)9-12/h2-10H,1H3,(H,17,18)

Upstream product

• 91818-29-0 2-cyano-N-(3-methoxyphenyl)acetamide 
• 98-80-6 phenylboronic acid 
• 23058-90-4 N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide 

Downstream Products

• 21280-55-7 7-methoxy-4-phenylquinoline 

Relevant articles and documents

Palladium catalysed hydrolysis-free arylation of aliphatic nitriles for the synthesis of 4-arylquinolin-2-one/pyrazolone derivatives

Palladium catalysed addition of arylboronic acid to the readily available 2-cyano-(N-aryl)-acetamide or ethyl-2-cyanoacetate followed by subsequent reaction transform them into the biologically significant 4-arylquinolin-2-one or pyrazolone derivatives. The reaction conditions are robust enough to prevent the hydrolysis of ester/amide moiety during arylation. In addition, the unactivated nitrile moiety in the acetonitrile also converted to the corresponding acetophenone derivative.

Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: Synthesis of 4-aryl-2-quinolinones

Figure presented A catalytic synthetic approach for the synthesis of 2-quinolinone compounds through a Pd-catalyzed C(sp2)-H functionalization/intramolecular amidation sequence is described. The cyclization process efficiently proceeds in the p