300356-11-0

Basic information

• Product Name: 3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid
• Synonyms: 3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid
• CAS NO: 300356-11-0
• Molecular Weight: 330.832
• Mol File: 300356-11-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid(300356-11-0)
• EPA Substance Registry System: 3-cyclopentyl-2-(3-chloro-4-methanesulfonylphenyl)propionic acid(300356-11-0)

Safety Data

• Hazardous Substances Data: 300356-11-0(Hazardous Substances Data)

Upstream product

• 300355-16-2 2-(3-chloro-4-methylsulfanylphenyl)-3-cyclopentylpropionic acid 
• 648905-09-3 4-bromo-2-chloro-1-(methylsulfonyl)benzene 
• 287-92-3 Cyclopentane 

Downstream Products

• 300354-07-8 2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(5-chloro-pyridin-2-yl)-propionamide 
• 588941-40-6 2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentyl-N-(pyrazin-2-yl)propanamide 
• 588941-11-1 2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-N-(2-methyl-pyrimidin-4-yl)-propionamide 
• 710322-41-1 N-(5-bromo-pyrazin-2-yl)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide 
• 710322-49-9 2-(3-chloro-4-methanesulfonyl-phenyl)-N-(5-cyanomethyl-pyrazin-2-yl)-3-cyclopentyl-propionamide 
• 1003013-99-7 (R)-3-cyclopentyl-2-(4-methanesulfonyl-3-methoxy-phenyl)-propionic acid 

Relevant articles and documents

Three-Component Alkene Difunctionalization by Direct and Selective Activation of Aliphatic C?H Bonds

Catalytic alkene difunctionalization is a powerful strategy for the rapid assembly of complex molecules and has wide range of applications in synthetic chemistry. Despite significant progress, a compelling challenge that still needs to be solved is the installation of highly functionalized C(sp3)-hybridized centers without requiring pre-activated substrates. We herein report that inexpensive and easy-to-synthesize decatungstate photo-HAT, in combination with nickel catalysis, provides a versatile platform for three-component alkene difunctionalization through direct and selective activation of aliphatic C?H bonds. Compared with previous studies, the significant advantages of this strategy are that the most abundant hydrocarbons are used as feedstocks, and various highly functionalized tertiary, secondary, and primary C(sp3)-hybrid centers can be easily installed. The practicability of this strategy is demonstrated in the selective late-stage functionalization of natural products and the concise synthesis of pharmaceutically relevant molecules including Piragliatin.

5-SUBSTITUTED-PYRAZINE OR PYRIDINE GLUCOKINASE ACTIVATORS

The present invention provides a compound according to formula (I) where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula (I) are also provided, said compounds being glucokinase activators which are useful in the treatment of type II diabetes.

Fused heteroaromatic glucokinase activators

Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.