300393-93-5

Basic information

• Product Name: 6-amino-4-phenyl-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• Synonyms: 6-amino-4-phenyl-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile;6-amino-4-phenyl-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• CAS NO: 300393-93-5
• Molecular Formula: C16H16N4O
• Molecular Weight: 280.32444
• Mol File: 300393-93-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-amino-4-phenyl-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-phenyl-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(300393-93-5)
• EPA Substance Registry System: 6-amino-4-phenyl-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile(300393-93-5)

Safety Data

• Hazardous Substances Data: 300393-93-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 29211-70-9 5-propyl-2,4-dihydro-3H-pyrazol-3-one 

Relevant articles and documents

Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPAR? partial agonists

Peroxisome proliferator-activated receptor ? (PPAR?) is a well-known target for thiazolidinedione antidiabetic drugs. In this paper, we present the synthesis and biological evaluation of a series of dihydropyrano[2,3-c]pyrazole derivatives as a novel family of PPAR? partial agonists. Two analogues were found to display high affinity for PPAR? with potencies in the micro molar range. Both of these hits were selective against PPAR?, since no activity was measured when tested against PPARα, PPAR? and RXRα. In addition, a novel modelling approach based on multiple individual flexible alignments was developed for the identification of ligand binding interactions in PPAR?. In combination with cell-based transactivation experiments, the flexible alignment model provides an excellent analytical tool to evaluate and visualize the effect of ligand chemical structure with respect to receptor binding mode and biological activity.