30078-48-9 Usage
Description
3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) is a white crystalline solid that is primarily used as a reference standard for the drug Trimethoprim. 3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) is a mixture of cis/trans isomers, which contributes to its unique chemical properties and applications.
Uses
Used in Pharmaceutical Industry:
3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) is used as a reference standard for the drug Trimethoprim. As a reference standard, it plays a crucial role in the development, quality control, and regulatory compliance of the drug, ensuring its efficacy and safety for medical use.
Used in Research and Development:
In the field of research and development, 3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) serves as a valuable compound for studying the chemical properties and interactions of Trimethoprim. This can lead to the discovery of new applications, improvements in drug formulation, and advancements in the pharmaceutical industry.
Used in Quality Control:
3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) is also utilized in the quality control process of pharmaceutical manufacturing. It helps in verifying the purity, potency, and consistency of Trimethoprim, ensuring that the final product meets the required standards for patient use.
Used in Regulatory Compliance:
In the context of regulatory compliance, 3-ANILINO-2-(3,4,5-TRIMETHOXYBENZYL) ACRYLONITRILE (25 MG) (AS) is essential for demonstrating the safety and efficacy of Trimethoprim to regulatory authorities. This helps in obtaining necessary approvals and ensuring that the drug is made available to patients in a safe and effective manner.
Check Digit Verification of cas no
The CAS Registry Mumber 30078-48-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,0,7 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 30078-48:
(7*3)+(6*0)+(5*0)+(4*7)+(3*8)+(2*4)+(1*8)=89
89 % 10 = 9
So 30078-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H20N2O3/c1-22-17-10-14(11-18(23-2)19(17)24-3)9-15(12-20)13-21-16-7-5-4-6-8-16/h4-8,10-11,13,21H,9H2,1-3H3/b15-13-
30078-48-9Relevant articles and documents
Practical preparation of trimethoprim: A classical antibacterial agent
Ji, Ya-Fei,Jiang, Jian-An,Liu, Hong-Wei,Liao, Dao-Hua,Wei, Xian-Yong
, p. 1517 - 1522 (2013/05/22)
An efficient, simple, and mild preparation of the classical antibacterial agent trimethoprim (1) was achieved in 85% overall yield from 3,4,5-trimethoxybenzaldehyde (2). First, the addition of propenenitrile (3) with dimethylamine almost quantitatively afforded 3-dimethylaminopropanenitrile (7). Then, by condensation of 7 with 2 as well as the continuous replacement of 3-dimethylamino group with aniline in situ, the key intermediate 3-anilino-2-(3,4,5-trimethoxybenzyl)propenenitrile (9) was obtained in an excellent yield of 91% with a one-pot procedure. Finally, the cyclization of 9 with guanidine nitrate furnished 1 in yields as good as 95% in the presence of the excessive sodium methoxide. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
