30100-83-5 Usage
Description
1-pentofuranosyldihydropyrimidine-2,4(1H,3H)-dione, also known as pentostatin, is a purine analog and a synthetic chemical compound that plays a significant role in the treatment of specific types of cancer, particularly hairy cell leukemia. It functions by inhibiting the activity of an enzyme crucial for DNA production, thereby preventing the multiplication and spread of cancer cells.
Uses
Used in Oncology:
1-pentofuranosyldihydropyrimidine-2,4(1H,3H)-dione is used as an anticancer agent for the treatment of hairy cell leukemia. It is administered intravenously and works by blocking the enzyme involved in DNA synthesis, which in turn stops the growth and spread of cancer cells.
Used in Cancer Treatment:
1-pentofuranosyldihydropyrimidine-2,4(1H,3H)-dione is used as a therapeutic agent in cancer treatment to improve patient outcomes. Its mechanism of action involves mimicking the structure and function of natural purine nucleosides, which allows it to effectively target and inhibit the enzymes necessary for cancer cell replication.
While the provided materials do not specify different industries for the use of 1-pentofuranosyldihydropyrimidine-2,4(1H,3H)-dione, its primary application is in the medical and pharmaceutical fields for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 30100-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,1,0 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 30100-83:
(7*3)+(6*0)+(5*1)+(4*0)+(3*0)+(2*8)+(1*3)=45
45 % 10 = 5
So 30100-83-5 is a valid CAS Registry Number.
30100-83-5Relevant articles and documents
Syntheses of β-D-Arabinofuranooxa(thia)zolidines
Skaric, Vinko,Matulic-Adamic, Jasenka
, p. 779 - 784 (2007/10/02)
Treatment of 2,2'-anhydro-1-(3,5-diacetoxy-β-D-arabinofuranosyl)-5,6-dihydrouracil (13) and its 2-thio analogue (17) with refluxing 80percent AcOH gives 3-propionamido-(3,5-diacetoxy-1,2-dideoxy-β-D-arabinofurano)oxazolidin-2-one (15) and 3-carboxyethyl-(3,5-diacetoxy-1,2-dideoxy β-D-arabinofurano)thiazolidin-2-imine (24), respectively.While the appearance of compound (15) indicates the occurence of an unusual C(2)-N(3) bond cleavage of (13) the 2-thio analogue (17) yields compound (24), the product of an N(3)-C(4) ring opening.The latter product gives first methoxycarbonylethyl(3,5-diacetoxy-1,2-dideoxy-β-D-arabinofurano)thiazolidine-2-imine hydrochloride (26) by reaction with methanolic HCl and subsequently the corresponding thiazolidin-2-thione (27) on reaction with H2S in DMF.The synthesis of the 1-(3,5-diacetoxy-2-acetylthio-β-D-arabinofuranosyl) derivative of 2-O-methyl-5,6-dihydrouracil (22) and 5,6-dihydroisocytosine (23) is also described.
