301186-43-6

Basic information

• Product Name: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropyl)piperidine-1-carboxylate
• CAS NO: 301186-43-6
• Molecular Weight: 335.419
• Mol File: 301186-43-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropyl)piperidine-1-carboxylate(301186-43-6)
• EPA Substance Registry System: tert-butyl 4-(3-(4-fluorophenyl)-3-oxopropyl)piperidine-1-carboxylate(301186-43-6)

Safety Data

• Hazardous Substances Data: 301186-43-6(Hazardous Substances Data)

Upstream product

• 110-71-4 1,2-dimethoxyethane 
• 352-13-6 4-flourophenylmagnesium bromide 
• 301186-40-3 N-methoxy-N-methyl-3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propionamide 
• 109-02-4 4-methyl-morpholine 
• 114615-82-6 tetrapropylammonium perruthennate 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 154775-43-6 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid 

Downstream Products

• 301186-44-7 4-(3-(4-fluorophenyl)-3-oxo-propyl)-1-(benzyloxycarbonyl)-piperidine 
• 301232-47-3 4-(3-(4-cyanophenyl)-3-oxo-propyl)-1-tert-butoxycarbonyl-piperidine 
• 301186-45-8 4-(3-(4-Fluorophenyl)-3-(RS)-hydroxy-3-(RS)methylpropyl)-1-(benzyloxycarbonyl)-piperidine 
• 76000-17-4 1-(4-fluorophenyl)-3-(piperidin-4-yl)-1-propanone 

Relevant articles and documents

The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression

Depression is one of the most frequent comorbid psychiatric symptoms of Alzheimer's disease (AD), and no efficacious drugs have been approved specifically for this purpose thus far. Herein, we proposed a novel therapeutic strategy that merged the key pharmacophores of the antidepressant vilazodone (5-HT1A receptor partial agonist and serotonin transporter inhibitor) and the anti-AD drug donepezil (acetylcholinesterase inhibitor) together to develop a series of multi-target-directed ligands for potential therapy of the comorbidity of AD and depression. Accordingly, 55 vilazodone-donepezil chimeric derivatives were designed and synthesized, and their triple-target activities against acetylcholinesterase, 5-HT1A receptor, and serotonin transporter were systematically evaluated. Among them, compound 5 displayed strong triple-target bioactivities in vitro, low hERG potassium channel inhibition and acceptable brain distribution. Importantly, oral intake of 5 mg/kg of the compound 5 dihydrochloride significantly alleviated the depressive symptoms and ameliorated cognitive dysfunction in mouse models. In brief, these results highlight vilazodone-donepezil chimeras as a prospective therapeutic approach for the treatment of the comorbidity of AD and depression.

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.