301223-53-0

Basic information

• Product Name: 3-Cyclobutyl-2(R)-[3(S)-(3-fluorophenyl)-4(S)-[4-[N-propyl-N-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-ylmethyl]pyrrolidin-1-yl]propionic acid
• CAS NO: 301223-53-0
• Molecular Formula: C₃₁H₄₁F₄N₅O₂
• Molecular Weight: 591.69832
• Mol File: 301223-53-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Cyclobutyl-2(R)-[3(S)-(3-fluorophenyl)-4(S)-[4-[N-propyl-N-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-ylmethyl]pyrrolidin-1-yl]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclobutyl-2(R)-[3(S)-(3-fluorophenyl)-4(S)-[4-[N-propyl-N-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-ylmethyl]pyrrolidin-1-yl]propionic acid(301223-53-0)
• EPA Substance Registry System: 3-Cyclobutyl-2(R)-[3(S)-(3-fluorophenyl)-4(S)-[4-[N-propyl-N-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-ylmethyl]pyrrolidin-1-yl]propionic acid(301223-53-0)

Safety Data

• Hazardous Substances Data: 301223-53-0(Hazardous Substances Data)

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 69034-12-4 2-chloro-5-(trifluoromethyl)pyrimidine 
• 206273-87-2 4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains

A new class of 4-(aminoheterocycle)piperidine derived 1,3,4 trisubstituted pyrrolidine CCR5 antagonists is reported. Compound 4a is shown to have good binding affinity (1.8 nM) and antiviral activity in PBMC's (IC95=50 nM). Compound 4a also has improved PK properties relative to 1.