30148-23-3

Basic information

• Product Name: 2-trichloroacetyl-1-methylimidazole
• Synonyms: 2-trichloroacetyl-1-methylimidazole
• CAS NO: 30148-23-3
• Molecular Weight: 227.477
• Mol File: 30148-23-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 272.3±50.0 °C(Predicted)
• Density: 1.56±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-trichloroacetyl-1-methylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-trichloroacetyl-1-methylimidazole(30148-23-3)
• EPA Substance Registry System: 2-trichloroacetyl-1-methylimidazole(30148-23-3)

Safety Data

• Hazardous Substances Data: 30148-23-3(Hazardous Substances Data)

Usage

Description

2-trichloroacetyl-1-methylimidazole is an organic compound characterized by its imidazole ring structure, with a methyl group at the first position and a trichloroacetyl group at the second position. This molecule exhibits unique chemical properties due to its functional groups, making it a versatile building block in various chemical reactions and applications.

Uses

Used in Chemical Synthesis:
2-trichloroacetyl-1-methylimidazole is used as a reactant for the synthesis of pyrrole-imidazole polyamide oligomers. These oligomers are significant in the development of DNA-binding molecules, which have potential applications in the fields of molecular biology and drug design.
Used in DNA-Binding Molecules:
2-trichloroacetyl-1-methylimidazole is also used as a building block for the synthesis of DNA-binding Py-Im polyamides. These polyamides are known for their ability to interact with DNA, which can be utilized in the development of novel therapeutic strategies targeting genetic disorders or diseases with a genetic component.

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 162085-97-4 methyl 4-amino-1-methyl-1H-imidazole-2-carboxylate 
• 128293-65-2 benzyl 4-((tert-butoxycarbonyl)amino)-1-methyl-1H-imidazole-2-carboxylate 
• 252206-28-3 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid 
• 20062-51-5 1-methyl-1H-imidazole-2-carboxamide 
• 864076-05-1 methyl 4-bromo-1-methyl-1H-imidazole-2-carboxylate 
• 1313196-95-0 1-methyl-4-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-2-carboxylic acid 
• 1313196-96-1 N-(2-amino-2-oxoethyl)-1-methyl-4-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-2-carboxamide 
• 1313196-10-9 ethyl 1-methyl-4-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-imidazole-2-carboxylate 

Relevant articles and documents

An improved synthesis of 1-methyl-2-trichloroacetylimidazole

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4-Methyltrityl-Protected Pyrrole and Imidazole Building Blocks for Solid Phase Synthesis of DNA-Binding Polyamides

DNA-binding polyamides are synthetic oligomers of pyrrole/imidazole units with high specificity and affinity for double-stranded DNA. To increase their synthetic diversity, we report a mild methodology based on 4-methyltrityl (Mtt) solid phase peptide synthesis (SPPS), whose building blocks are more accessible than the standard Fmoc and Boc SPPS ones. We demonstrate the robustness of the approach by preparing and studying a hairpin with all precursors. Importantly, our strategy is orthogonal and compatible with sensitive molecules and could be readily automated.

AMIDE COMPOUND

A compound represented by the formula (I) wherein ring Cy1 is a 5-membered aromatic heterocycle optionally further substituted besides a group represented by -A-B, ring Cy2 is an optionally substituted benzene ring, ring Cy3 is an optionally substituted 5-membered aromatic heterocycle, ring Cy4 is an optionally substituted 6-membered aromatic ring, A is -CONRa- or -NRaCO-, Ra is a hydrogen atom or a substituent, B is a hydrogen atom or an optionally substituted C1-6 alkyl-group, X is an optionally substituted C1-2 alkylene, -Y-, -Y-CH2- or - CH2-Y-, Y is an oxygen atom, -NRb- or -S(O)m-, Rb is a hydrogen atom or a substituent, and m is 0, 1 or 2, provided that N-methyl-4-[2-[3,4,5-trimethoxyphenyl)amino]-1,3-benzoxazol-7-yl]thiophene-2-carboxamide is excluded, or a salt thereof, has an agonistic action on GPR52, and is useful as an agent for the prophylaxis or treatment of schizophrenia and the like.