301544-46-7

Basic information

• Product Name: (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester
• Synonyms: (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester
• CAS NO: 301544-46-7
• Molecular Weight: 532.637
• Mol File: 301544-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester(301544-46-7)
• EPA Substance Registry System: (S)-2-((R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester(301544-46-7)

Safety Data

• Hazardous Substances Data: 301544-46-7(Hazardous Substances Data)

Upstream product

• 2462-35-3 L-leucine benzyl ester hydrochloride 
• 2448-45-5 Cbz-D-Phe 
• 58917-85-4 N-(benzyloxycarbonyl)-D-phenylalaninol 
• 63219-70-5 N-(benzyloxycarbonyl)-D-phenylalaninal 
• 301544-37-6 (S)-2-Isocyano-4-methyl-pentanoic acid benzyl ester 

Downstream Products

• 58970-76-6 bestatin 

Relevant articles and documents

New synthetic technology for efficient construction of α-hydroxy-β-amino amides via the passerini reaction

The Passerini reaction of N-protected amino aldehydes, isonitriles, and TFA using pyridine-type bases proceeds under mild conditions and directly affords α-hydroxy-β-amino amide derivatives in moderate to high yields. These adducts are readily hydrolyzed to αhydroxy-β-amino carboxylic acids. Application of these key intermediates to concise syntheses of P1-α-ketoamide protease inhibitors is illustrated.