3016-20-4

Basic information

• Product Name: (2E,4E)-2,4-dibenzylidene-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one
• Synonyms: (2E,4E)-2,4-dibenzylidene-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one
• CAS NO: 3016-20-4
• Molecular Weight: 315.415
• Mol File: 3016-20-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2E,4E)-2,4-dibenzylidene-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-2,4-dibenzylidene-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(3016-20-4)
• EPA Substance Registry System: (2E,4E)-2,4-dibenzylidene-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(3016-20-4)

Safety Data

• Hazardous Substances Data: 3016-20-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 532-24-1 tropinone 

Downstream Products

• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 677008-53-6 2α,4α-dibenzyltropanone 

Relevant articles and documents

Application of monocarbonyl curcumin compound in preparation of medicine for preventing and treating periodontitis

The invention belongs to the technical field of medicines, and particularly relates to application of a specific monocarbonyl curcumin analogue in preparation of a medicine for preventing and treating periodontitis. Experiments prove that the monocarbonyl curcumin analogues not only can play a better anti-oxidation protection role by activating an Nrf2/HO-1 signal channel, but also can play an anti-inflammatory role by inhibiting release of inflammatory factors TNF alpha and IL1-beta, so that the monocarbonyl curcumin analogues have a remarkable prevention and treatment effect on rat periodontitis, have good potential value and significance for prevention and treatment of periodontitis, and have a good research and development prospect.

The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones

An efficient and versatile two-step synthesis of 2-arylmethylidene-8- methyl-8-azabicyclo[3.2.1]octane-3-ones, via mono aldol condensation of tropinone with a variety of aryl aldehydes followed by pTsOH-catalyzed dehydration, is described.