301695-61-4Relevant articles and documents
A stereoselective synthesis of squalamine
Zhou, Xiang-Dong,Cai, Feng,Zhou, Wei-Shan
, p. 10293 - 10299 (2002)
Squalamine (1) was synthesized stereoselectively in 14 steps and 19% overall yield from 3-keto-5α-chenodeoxycholanate (2) by using a modified Sharpless asymmetric dihydroxylation as the key step.
Study on synthesis of key squalamine intermediate 7α, 24R-dihydroxy-5α-cholestan-3-one
Zhou, Shuai,Zheng, Yang,Yang, Beibei,Zhong, Jiawei,Shi, Haijian
, (2019)
A facile novel strategy has been developed to obtain a key intermediate of squalamine, 7α, 24R -dihydroxy-5α-cholestan-3-one, starting from methyl Δ5-3β-hydroxycholanate. The pure product was successfully synthesized and separated from the C-24
Formal synthesis of squalamine from desmosterol
Okumura, Kazuo,Nakamura, Yutaka,Takeuchi, Seiji,Kato, Isao,Fujimoto, Yoshinori,Ikekawa, Nobuo
, p. 1177 - 1182 (2007/10/03)
The key intermediate to squalamine, (5α, 7α, 24R)-7,24-dihydroxy-cholestan-3-one, was synthesized from the 3-O-acetyl-24R,25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7.