30202-92-7

Basic information

• Product Name: 4-(2-aminophenoxy)benzonitrile
• Synonyms: 4-(2-aminophenoxy)benzonitrile
• CAS NO: 30202-92-7
• Molecular Formula: C₁₃H₁₀N₂O
• Molecular Weight: 210.2313
• Mol File: 30202-92-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-aminophenoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-aminophenoxy)benzonitrile(30202-92-7)
• EPA Substance Registry System: 4-(2-aminophenoxy)benzonitrile(30202-92-7)

Safety Data

• Hazardous Substances Data: 30202-92-7(Hazardous Substances Data)

Usage

General Description

4-(2-aminophenoxy)benzonitrile is a chemical compound with the molecular formula C13H10N2O. It is a white to off-white solid powder with a molecular weight of 210.23 g/mol. 4-(2-aminophenoxy)benzonitrile is often used in the synthesis of pharmacological drugs and as a building block in organic chemistry. It is also known for its potential use in the development of pharmaceuticals and agrochemicals. 4-(2-aminophenoxy)benzonitrile is considered to be a valuable intermediate in the production of various functional materials, such as liquid crystals and pharmaceutical compounds. Additionally, it may have potential applications in the field of material science and other related industries.

Upstream product

• 767-00-0 4-cyanophenol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 113344-23-3 4-(2-nitrophenoxy)benzonitrile 

Downstream Products

• 76838-23-8 1-Benzoyl-3-[2-(4-cyano-phenoxy)-phenyl]-thiourea 
• 76839-04-8 [2-(4-Cyano-phenoxy)-phenyl]-thiourea 
• 76840-98-7 4-[2-(Imidazolidin-2-ylideneamino)-phenoxy]-benzonitrile 

Relevant articles and documents

Discovery of Benzamidine- And 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

Mas-related G-protein-coupled receptor X1 (MRGPRX1) is a human sensory neuron-specific receptor and has been actively investigated as a therapeutic target for the treatment of pain. By use of two HTS screening hit compounds, 4-(4-(benzyloxy)-3-methoxybenzylamino)benzimidamide (5a) and 4-(2-(butylsulfonamido)-4-methylphenoxy)benzimidamide (11a), as molecular templates, a series of human MRGPRX1 agonists were synthesized and evaluated for their agonist activity using HEK293 cells stably transfected with human MrgprX1. Conversion of the benzamidine moiety into a 1-aminoisoquinoline moiety carried out in the later stage of structural optimization led to the discovery of a highly potent MRGPRX1 agonist, N-(2-(1-aminoisoquinolin-6-yloxy)-4-methylphenyl)-2-methoxybenzenesulfonamide (16), not only devoid of positively charged amidinium group but also with superior selectivity over opioid receptors. In mice, compound 16 displayed favorable distribution to the spinal cord, the presumed site of action for the MRGPRX1-mediated analgesic effects.