30203-94-2

Basic information

• Product Name: Benzene, 1-chloro-4-[(4-nitrophenyl)methyl]-
• CAS NO: 30203-94-2
• Molecular Formula: C13H10ClNO2
• Molecular Weight: 247.681
• Mol File: 30203-94-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-[(4-nitrophenyl)methyl]-(30203-94-2)
• EPA Substance Registry System: Benzene, 1-chloro-4-[(4-nitrophenyl)methyl]-(30203-94-2)

Safety Data

• Hazardous Substances Data: 30203-94-2(Hazardous Substances Data)

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 1679-18-1 4-Chlorophenylboronic acid 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 104-03-0 4-nitrobenzeneacetic acid 
• 106-39-8 bromochlorobenzene 
• 42766-39-2 potassium 2-(4-nitrophenyl)acetate 
• 636-98-6 p-nitrobenzene iodide 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 
• 100-14-1 4-nitrobenzyl chloride 
• 108-90-7 chlorobenzene 
• 7446-70-0 aluminium trichloride 
• 27297-82-1 4-Brom-benzolsulfonsaeure-(4-nitro-benzyl)-ester 

Downstream Products

• 50275-07-5 4-amino-4'-chlorodiphenylmethane 
• 71969-52-3 3,4'-diamino-4-chloro-benzophenone 
• 4913-77-3 4-amino-4'-chlorobenzophenone 
• 37567-38-7 4-chloro-3,4'-dinitro benzophenone 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 

Relevant articles and documents

Dual copper- and photoredox-catalysed C(sp2)-C(sp3) coupling

The use of copper catalysis with visible light photoredox catalysis in a cooperative fashion has recently emerged as a versatile means of developing new C-C bond forming reactions. In this work, dual copper and photoredox catalysis is exploited to effect C(sp2)-C(sp3) cross-couplings between aryl boronic acids and benzyl bromides.

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors

Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral drugs, and several keto - enol acid class (often referred to as diketo acid class) inhibitors have clinically exhibited-marked antiretroviral activity. Here, we show the synthesis and the detailed structure - activity relationship of the quinolone carboxylic acids as a novel monoketo acid class of integrase inhibitors. 6-(3-Chloro-2-fluorobenzyl)-1-((2S)-1-hydroxy-3,3- dimethylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 51, which showed an IC50 of 5.8 nMin the strand transfer assay and an ED50 of 0.6 nMin the antiviral assay, and 6-(3-chloro-2-fluorobenzyl) -1-((2S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3- carboxylic acid 49, which had an IC50 of 7.2 nMand an ED50 of 0.9 nM, were the most potent compounds in this class. The monoketo acid 49 was much more potent at inhibiting integrasecatalyzed strand transfer processes than 3′-processing reactions, as is the case with the keto - enol acids. Elvitegravir 49 was chosen as a candidate for further studies and is currently in phase 3 clinical trials.