30233-64-8 Usage
Description
MONOBEHENIN, also known as Glyceryl Behenate, is a monoester of glycerol and behenic acid. It is a fine white-yellow powder, hard waxy mass, or white or almost white unctuous flakes with a faint odor. It is widely used in various industries due to its unique properties.
Uses
Used in Cosmetics and Personal Care Industry:
MONOBEHENIN is used as an emollient, emulsifier, and viscosity increasing agent in cosmetics and personal care products. It helps to improve the texture, spreadability, and stability of the formulations, providing a smooth and silky feel on the skin.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, MONOBEHENIN is used as a solidifying agent, emulsifier, and viscosity increasing agent in various formulations such as tablets, capsules, and topical creams. It enhances the stability, release, and absorption of active ingredients, improving the overall efficacy of the products.
Used in Food Industry:
MONOBEHENIN is used as a thickener, emulsifier, and stabilizer in the food industry. It helps to improve the texture, consistency, and shelf life of various food products, such as baked goods, confectionery, and beverages.
Used in Plastics and Polymer Industry:
In the plastics and polymer industry, MONOBEHENIN is used as a lubricant, plasticizer, and viscosity modifier. It helps to improve the processability, flexibility, and performance of various plastic and polymer materials, such as films, coatings, and adhesives.
Production Methods
Glyceryl behenate is prepared by the esterification of glycerin by
behenic acid (C22 fatty acid) without the use of catalysts. In the case
of Compritol 888 ATO (Gattefosse′), raw materials used are of
vegetable origin, and the esterified material is atomized by spraycooling.
Pharmaceutical Applications
Glyceryl behenate is used in cosmetics, foods, and oral pharmaceutical
formulations.
In pharmaceutical formulations, glyceryl behenate is mainly used
as a lubricant in the preparation of oral tablets and capsules. It
has good binding properties, it does not affect tablet hardness and is
unaffected by mixing or production parameters. Glyceryl behenate
has been investigated for the encapsulation of various drugs such as
retinoids. It has also been investigated for use in the preparation
of sustained-release tablets; as a matrix-forming agent for the
controlled release of water-soluble drugs; and it can also be used
as a hot-melt coating agent sprayed onto a powder or drug-loaded
sugar beads and granules. It may also be incorporated via
extrusion/spheronization into pellets, which can be further compressed
into tablets.
Glyceryl behenate is used in oral enteric-coated pellets, powders
and suspensions. It is also used in controlled, extended-release and
orally disintegrating tablets. For oral preparations, glyceryl
behenate forms a lipidic matrix for sustained-release formulations.
It has been used along with acid-soluble or swellable polymers to
mask the bitter or unpleasant taste of the medicament with
improved palatability.
Glyceryl behenate has been used for the preparation of
ophthalmic inserts.
In cosmetics, glyceryl behenate is used as a skin conditioning
agent, emollient and viscosity-increasing agent in emulsions. It also
improves the heat stability of emulsions and is a gelifying agent for
various oils. For topical formulations, it is used as a thickening
agent for oily phases. It is also used as a surfactant or emulsifying
agent.
Safety
Glyceryl behenate is used in cosmetics, foods and oral pharmaceutical
formulations, and is generally regarded as a relatively
nonirritant and nontoxic material. The US Cosmetic Ingredients
Review Expert Panel evaluated glyceryl behenate and concluded
that it is safe for use in cosmetic formulations in present practices of
use and concentration.
LD50 (mouse, oral): 5 g/kg
storage
Glyceryl behenate should be stored in a tightly closed container, at a
temperature less than 35°C.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral capsules,
tablets, and suspensions). Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 30233-64-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,3 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 30233-64:
(7*3)+(6*0)+(5*2)+(4*3)+(3*3)+(2*6)+(1*4)=68
68 % 10 = 8
So 30233-64-8 is a valid CAS Registry Number.
InChI:InChI=1/C25H50O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(28)29-24(22-26)23-27/h24,26-27H,2-23H2,1H3
