30244-37-2Relevant articles and documents
Taxanes from the roots of Taxus mairei
Shen, Ya-Ching,Chen, Ching-Yeu
, p. 1527 - 1533 (1997)
Extensive column chromatography of the ethanolic extracts from the roots of Taxus mairei and subsequent purification of taxanes by HPLC gave two derivatives of baccatin 1 and one derivative of taxchin. The structural assignments of the taxoids were based on their spectral data, including 2D NMR experiments and chemical correlation. X-ray crystallographic analysis of 1β-hydroxybaccatin 1 provided unambiguous characterization for the structures and relative stereochemistries of the other taxanes.
Bioactive taxoids from Japanese yew Taxus Cuspidata and taxol biosynthesis
Kobayashi, Jun'ichi,Shigemori, Hideyuki
, p. 1111 - 1133 (2007/10/03)
A series of new taxoids, named taxuspines A ～ H and J ～ Z (1 ～ 25), have been isolated together with 37 known taxoids (26 ～ 62) including taxol (42) from the Japanese yew Taxus cuspidata Sieb. et Zucc. These new taxoids possessed various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl2-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids as well as recent development of taxol biosynthesis.
