3028-97-5

Basic information

• Product Name: DASBTI
• Synonyms: DASBTI;2-[4-(dimethylamino)styryl]-3-ethylbenzothiazolium iodide
• CAS NO: 3028-97-5
• Molecular Formula: C₁₉H₂₁N₂S*I
• Molecular Weight: 0
• Mol File: 3028-97-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DASBTI(CAS DataBase Reference)
• NIST Chemistry Reference: DASBTI(3028-97-5)
• EPA Substance Registry System: DASBTI(3028-97-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 3028-97-5(Hazardous Substances Data)

Usage

Description

DASBTI, with the molecular formula C22H36N2O6, is a chemical compound derived from the amino acid tyrosine. It has demonstrated potential therapeutic properties for the treatment of various conditions, such as cancer and neurodegenerative diseases. DASBTI is recognized for its ability to inhibit cancer cell growth and induce apoptosis, positioning it as a promising candidate for anticancer drug development. Moreover, it exhibits neuroprotective effects by reducing brain cell damage and inflammation, suggesting its potential as a treatment for Alzheimer's disease and Parkinson's disease. Further research is essential to fully comprehend the mechanisms of action and the scope of DASBTI's applications in medical treatments.

Uses

Used in Pharmaceutical Industry:
DASBTI is used as an anticancer agent for its ability to inhibit the growth of cancer cells and induce apoptosis, making it a potential candidate for the development of new cancer treatments.
Used in Neurodegenerative Disease Treatment:
DASBTI is used as a neuroprotective agent due to its capacity to reduce brain cell damage and inflammation, which may offer potential therapeutic benefits for conditions such as Alzheimer's disease and Parkinson's disease.

InChI:InChI=1/C19H21N2S.HI/c1-4-21-17-7-5-6-8-18(17)22-19(21)14-11-15-9-12-16(13-10-15)20(2)3;/h5-14H,4H2,1-3H3;1H/q+1;/p-1

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 3119-93-5 N-ethyl-2-methylbenzothiazolium iodide 
• 120-75-2 2-Methylbenzothiazole 

Relevant articles and documents

Highly selective turn-on red fluorescence probes for visualization of the G-quadruplexes DNA in living cells

Studies on small molecule fluorescent probes for detecting G-quadruplexes DNA have bring about an extensive attention in recent years. In this paper, we designed and synthesized three benzothiazole derivatives named 2a-2c under moderate reaction conditions and investigated their interactions with DNA (single-stranded, duplex, i-motif and G-quadruplex) and distribution in living cell. Three compounds present a large Stokes shift (～90 nm) and a weak red fluorescence emission, and they exhibit a good selectivity and sensitive turn-on fluorescence response for the promoter G-quadruplex DNA (bcl-2, c-myc and c-kit 2) and mitochondria G-quadruplex (KSS). The affinity of 2a and 2b with N-alkyl side chain group to DNA is stronger than that of 2c with an anion group, therefore, they also increase the stability of the G-quadruplex structure. 2b induces the conformational change of both bcl-2 and KSS G-quadruplexes, while all compounds induce the folding of bcl-2 from the coiled structure to the hybrid G-qrudruplex. Three compounds interact with the G-quadruplex DNA mainly by end-stacking mode. Furthermore, MTT assays and confocal fluorescence images show that these compounds can enter the living HepG2 cells with low cytotoxicity. 2a-2c are mainly located in the mitochondrion and interacted with mitochondria G-quadruplex DNA, while only weak fluorescence can be found in cell nucleus. In a word, 2a-2c can be implied in image of G-quadruplex DNA in living cells.