3029-64-9 Usage
Description
2,4,6-TRICHLORO-5-CYANOPYRIMIDINE is an organic compound with the molecular formula C5HCl3N4. It is characterized by the presence of three chlorine atoms and a cyano group attached to a pyrimidine ring. 2,4,6-TRICHLORO-5-CYANOPYRIMIDINE is known for its potential applications in the pharmaceutical industry, particularly in the development of inhibitors for specific protein targets.
Uses
Used in Pharmaceutical Industry:
2,4,6-TRICHLORO-5-CYANOPYRIMIDINE is used as a chemical intermediate for the synthesis of phosphoinositide 3-Kinase (PI3K) β/δ inhibitors. These inhibitors are designed to target and modulate the activity of PI3K β/δ enzymes, which play a crucial role in cellular signaling pathways involved in various diseases, including cancer.
The development of PI3K β/δ inhibitors using 2,4,6-TRICHLORO-5-CYANOPYRIMIDINE as a key intermediate aims to provide novel therapeutic options for the treatment of phosphatase and Tensin Homolog (PTEN) deficiency. PTEN is a tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, which is often dysregulated in various cancers. By targeting PI3K β/δ enzymes, these inhibitors can potentially restore the balance of the PI3K/AKT pathway and exhibit anti-cancer effects.
Check Digit Verification of cas no
The CAS Registry Mumber 3029-64-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,2 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3029-64:
(6*3)+(5*0)+(4*2)+(3*9)+(2*6)+(1*4)=69
69 % 10 = 9
So 3029-64-9 is a valid CAS Registry Number.
InChI:InChI=1/C5Cl3N3/c6-3-2(1-9)4(7)11-5(8)10-3
3029-64-9Relevant articles and documents
PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF
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Paragraph 0086; 0088, (2019/08/30)
The present application relates to a pyrazolopyrimidine compound of Formula (I) and a pharmaceutically acceptable salt thereof. Such compounds can be used to inhibit the activity of a lipid kinase PI3K, and can also be used to treat diseases mediated by P
Herbicidal 5-pyrimidinecarbonitriles
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, (2008/06/13)
5-Pyrimidinecarbonitriles, having amino substituents in the 2 and 6 positions and an alkoxy substituent in the 4 position, exhibit herbicidal activity. The preparation of novel active compounds and intermediates in this class is described; herbicidal compositions containing the active compounds are illustrated; and methods for utilizing the herbicidal compositions to control plant growth are disclosed.
