30312-36-8

Basic information

• Product Name: 2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline
• Synonyms: 2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline
• CAS NO: 30312-36-8
• Molecular Weight: 223.318
• Mol File: 30312-36-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline(30312-36-8)
• EPA Substance Registry System: 2-methyl-4-phenyl-1,2,3,4-tetrahydroquinoline(30312-36-8)

Safety Data

• Hazardous Substances Data: 30312-36-8(Hazardous Substances Data)

Upstream product

• 1721-92-2 2-methyl-4-phenylquinoline 
• 100-42-5 styrene 
• 62-53-3 aniline 
• 75-05-8 acetonitrile 
• 540-37-4 p-aminoiodobenzene 
• 91-17-8 decalin 

Downstream Products

• 1721-92-2 2-methyl-4-phenylquinoline 

Relevant articles and documents

Metal-Free One-Pot Synthesis of (Tetrahydro)Quinolines through Three-Component Assembly of Arenediazonium Salts, Nitriles, and Styrenes

A highly efficient and convenient metal-free, one-pot synthesis of diversely substituted (tetrahydro)quinolines has been achieved through a three-component assembly reaction of arenediazonium salts, nitriles, and styrenes. In sharp contrast to the prior works with the same reagent blend, the formation of N-arylnitrilium intermediates from arenediazonium salts and nitriles was followed by reaction with styrenes, leading to 3,4-dihydroquinolinium salts as a common intermediate. These could be further transformed to quinolines and tetrahydroquinolines depending on the reaction conditions. The advantages of this protocol include its simplicity, metal-free and mild conditions, readily available starting materials, and good functional group tolerance. (Figure presented.).