303162-38-1

Basic information

• Product Name: 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine
• Synonyms: 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine
• CAS NO: 303162-38-1
• Molecular Weight: 281.381
• Mol File: 303162-38-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine(303162-38-1)
• EPA Substance Registry System: 4-[2-methyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine(303162-38-1)

Safety Data

• Hazardous Substances Data: 303162-38-1(Hazardous Substances Data)

Usage

Chemical Structure

C18H16N4S

Classification

Heterocyclic compound

Components

Thiazole ring, pyridine ring

Usage

Pharmaceutical and chemical industries
Potential medicinal properties

Applications

Drug discovery
Biochemistry
Medicinal chemistry

Research and Development

Suitable for research and development
Unique structure for exploring potential medicinal properties

Synthesis

Potential as a building block for synthesizing complex molecules
Functional groups for versatile chemical reactions

Upstream product

• 365428-99-5 [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetic acid 
• 303162-37-0 2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone 
• 62-55-5 thioacetamide 
• 90101-20-5 tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate 
• 21384-43-0 1-(3-methylbenzoyl)-2-methylaziridine 
• 365428-80-4 ethyl [5-(2-amino-4-pyridyl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]acetate 

Relevant articles and documents

Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent

The p38 mitogen-activated protein (MAP) kinase has been implicated in the proinflammatory cytokine signal pathway, and its inhibitors are potentially useful for the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA) and inflammat

Substituted 1,3-thiazole compounds, their production and use

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

An optionally N-oxidized compound represented by the formula: wherein R1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R2 represents an aromatic group, R3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR4 (R4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.