3034-55-7 Usage
Description
5-Bromothiazole is a monobromothiazole compound that can be synthesized through the treatment of 2,5-dibromothiazole with sodium ethoxide, followed by hydrogenation over spongy nickel. It is a significant chemical intermediate and performance material with various applications across different industries.
Uses
Used in Pharmaceutical Industry:
5-Bromothiazole is used as a pharmaceutical intermediate for the development of various drugs. Its unique chemical structure allows it to be a key component in the synthesis of therapeutic agents, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Performance Materials:
In the field of performance materials, 5-Bromothiazole is utilized for its specific properties that can enhance the characteristics of materials used in various applications. Its incorporation can lead to improved performance in areas such as chemical resistance, thermal stability, and mechanical strength, making it a valuable addition to the development of high-performance materials.
Purification Methods
If bromothiazole is too coloured, then suspend it in dilute NaOH and steam distil it. Add NaCl to the aqueous distillate, extract it with Et2O, dry it (Na2SO4), evaporate and fractionate the residue in a vacuum. The HgCl2 salt crystallises from EtOH with m 148o (dec). [Beyerman et al. Recl Trav Chim, Pays Bas 73 330 1954, Beilstein 27 III/IV 962.]
Check Digit Verification of cas no
The CAS Registry Mumber 3034-55-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,3 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3034-55:
(6*3)+(5*0)+(4*3)+(3*4)+(2*5)+(1*5)=57
57 % 10 = 7
So 3034-55-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H2BrNS/c4-3-1-5-2-6-3/h1-2H
3034-55-7Relevant articles and documents
Synthesis of Brominated Thiazoles via Sequential Bromination-Debromination Methods
Uzelac, Eric J.,Rasmussen, Seth C.
, p. 5947 - 5951 (2017/06/07)
The synthesis of the full family of bromothiazoles has been revisited in order to update and optimize their production. The species reported include 2-bromothiazole, 4-bromothiazole, 5-bromothiazole, 2,4-dibromothiazole, 2,5-dibromothiazole, 4,5-dibromothiazole, and 2,4,5-tribromothiazole, the majority of which are produced via sequential bromination and debromination steps. This complete family can now be produced without the use of elemental bromine, and the presented methods have allowed the physical and NMR spectroscopic characterization of the full family to be reported for the first time.
HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS
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Page/Page column 40-41, (2008/12/05)
This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.
Synthesis of Stannylthiazoles and Mixed Stannylsilylthiazoles and their Use for a Convenient Preparation of Mono- and Bis-halothiazoles
Dondoni, A.,Mastellari, A. R.,Medici, A.,Negrini, E.,Pedrini, P.
, p. 757 - 760 (2007/10/02)
Stannylthiazoles and stannyl-silylthiazoles have been prepared and employed as thiazolyl carbanion equivalents in reactions with halogens to give mono- and mixed bis-halothiazoles in good yields.