30345-85-8

Basic information

• Product Name: 1-BENZYL-1H-IMIDAZOLE-2,4,5(3H)-TRIONE
• Synonyms: 1-BENZYL-1H-IMIDAZOLE-2,4,5(3H)-TRIONE;1-benzylimidazolidine-2,4,5-trione
• CAS NO: 30345-85-8
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.18
• Mol File: 30345-85-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 167-169 °C
• Appearance: /
• Density: 1.421±0.06 g/cm3(Predicted)
• PKA: 6.39±0.20(Predicted)
• CAS DataBase Reference: 1-BENZYL-1H-IMIDAZOLE-2,4,5(3H)-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-1H-IMIDAZOLE-2,4,5(3H)-TRIONE(30345-85-8)
• EPA Substance Registry System: 1-BENZYL-1H-IMIDAZOLE-2,4,5(3H)-TRIONE(30345-85-8)

Safety Data

• Hazardous Substances Data: 30345-85-8(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 91360-74-6 N-Benzyl-N'-(trimethylsilyl)carbodiimid 
• 3287-99-8 benzylamine hydrochloride 
• 14856-79-2 N-benzyl(trimethylsilyl)amine 

Downstream Products

• 128043-60-7 ethyl (3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)ethanoate 
• 1086764-74-0 C₁₃H₁₂N₂O₅ 
• 1086764-86-4 4-[(3-benzylureido)methyl]benzoic acid 
• 1086764-89-7 C₁₄H₁₄N₂O₄ 
• 34582-50-8 2-Phenyl-5-benzyl-hydantoinsaeure 
• 1294400-89-7 3-(3-benzyl-2,4,5-trioxo-imidazolidin-1-yl)-propionamide 

Relevant articles and documents

Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5- trioxoimidazolidine-1-acetic acids

A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)IC50(AR) was > 1000 in some compounds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5- trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.

β-Lactam via N-silylcarbodiimides

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