30374-65-3

Basic information

• Product Name: Ni(P(C₆H₁₁)3)2H(Br)
• CAS NO: 30374-65-3
• Molecular Weight: 700.469
• Mol File: 30374-65-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ni(P(C₆H₁₁)3)2H(Br)(CAS DataBase Reference)
• NIST Chemistry Reference: Ni(P(C₆H₁₁)3)2H(Br)(30374-65-3)
• EPA Substance Registry System: Ni(P(C₆H₁₁)3)2H(Br)(30374-65-3)

Safety Data

• Hazardous Substances Data: 30374-65-3(Hazardous Substances Data)

Upstream product

• 760-19-0 diethylaluminum bromide 
• 2622-14-2 tricyclohexylphosphine 
• 16940-66-2 sodium tetrahydroborate 
• 24510-62-1 bis(tricyclohexylphosphine)nickel(II) bromide 

Downstream Products

• 129370-37-2 {Cy₃PH}{(Cy₃P)NiBr₃} 

Relevant articles and documents

Nickel-catalyzed hydrogen-borrowing strategy: Chemo-selective alkylation of nitriles with alcohols

The first nickel-catalyzed hydrogen-borrowing alkylation of a series of aryl acetonitriles with a variety of aryl, heteroaryl, allylic and alkyl alcohols releasing water as the by-product (>33 examples, up to 90% yield) is reported.

Nickel-Catalyzed Hydrogen-Borrowing Strategy for α-Alkylation of Ketones with Alcohols: A New Route to Branched gem-Bis(alkyl) Ketones

The α-alkylation of ketones using an earth-abundant and nonprecious NiBr2/L1 system is reported. This nickel-catalyzed reaction could be performed in gram scale and successfully applied in the synthesis of donepezil (Alzheimer's drug) and functionalization of steroid hormones and fatty acid derivatives. Synthesis of N-heterocycles, methylation of ketones, and one-pot double alkylation to bis-hetero aryl ketones using two different alcohols with a single catalyst broadens the scope of the catalytic protocol. Preliminary mechanistic studies using defined Ni-H species and deuterium-labeling experiments established the participation of the borrowing-hydrogen strategy.