30411-90-6

Basic information

• Product Name: [1-amino-3-(methylsulfanyl)propyl]phosphonic acid
• Synonyms: (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHONIC ACID; phosphonic acid, [1-amino-3-(methylthio)propyl]-
• CAS NO: 30411-90-6
• Molecular Formula: C₄H₁₂NO₃PS
• Molecular Weight: 185.1817
• Mol File: 30411-90-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 391.9°C at 760 mmHg
• Flash Point: 190.8°C
• Density: 1.405g/cm³
• Vapor Pressure: 3.11E-07mmHg at 25°C
• Refractive Index: 1.55
• PKA: 0.71±0.10(Predicted)
• CAS DataBase Reference: [1-amino-3-(methylsulfanyl)propyl]phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [1-amino-3-(methylsulfanyl)propyl]phosphonic acid(30411-90-6)
• EPA Substance Registry System: [1-amino-3-(methylsulfanyl)propyl]phosphonic acid(30411-90-6)

Safety Data

• Hazardous Substances Data: 30411-90-6(Hazardous Substances Data)

Upstream product

• 3268-49-3 3-(methylsulfenyl)propanal 
• 762-04-9 phosphonic acid diethyl ester 
• 77275-27-5 diphenyl 1-(3-phenylthioureido)methylthiopropylphosphonate 
• 101-02-0 triphenyl phosphite 
• 103-85-5 monophenylthiourea 
• 67896-53-1 [1-(R,S)-amino-3-(methylsulphanyl)propyl]phosphinic acid 

Downstream Products

• 81979-41-1 Phosphomethionine sulfoxide 
• 81979-40-0 1-Amino-3-p-nitrobenzylthiopropanephosphonic acid 
• 77275-38-8 [(RS)-1-amino-3-(benzylsulfanyl)propyl]phosphonic acid 

Relevant articles and documents

Conversion of nitriles to 1-aminophosphonic acids and preparation of phosphahomocysteines of high enantiomeric excess

A variety of nitriles was reduced to diisobutylaluminum salts of aldimines, to which diisopropyl phosphite was added. The corresponding 1-aminophosphonates were either deprotected to give racemic 1-aminophosphonic acids or reacted with Boc2O to yield N-Boc-protected 1-aminophosphonates. The enantiomers of 2-benzylthio-1-(t-butoxycarbonylamino)propylphosphonate were obtained from the racemate by chiral HPLC and converted to phosphonic acid analogs of (R)- and (S)-homocysteine, (R)- and (S)-2-aminobutyric acid and (S)-methionine, all of ee >97% as determined by chiral HPLC.

Enantioselective synthesis of diverse α-amino phosphonate diesters

An efficient, versatile protocol for the synthesis of highly enantioenriched α-amino phosphonate diesters has been devised. Addition of lithium diethyl phosphite to chiral chelating imines 31a-j, prepared from a variety of aldehydes and the chiral auxilia

Phosphohomocysteine Derivatives

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