30435-75-7

Basic information

• Product Name: Benzene, 1-bromo-2-methoxy-5-methyl-3-nitro-
• Synonyms: 1-bromo-2-methoxy-5-methyl-3-nitro-benzene;3-Bromo-4-methoxy-5-nitrotoluol
• CAS NO: 30435-75-7
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.06
• Mol File: 30435-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-2-methoxy-5-methyl-3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-methoxy-5-methyl-3-nitro-(30435-75-7)
• EPA Substance Registry System: Benzene, 1-bromo-2-methoxy-5-methyl-3-nitro-(30435-75-7)

Safety Data

• Hazardous Substances Data: 30435-75-7(Hazardous Substances Data)

Upstream product

• 22002-45-5 2-bromo-4-methylanisole 
• 108-24-7 acetic anhydride 
• 20039-91-2 2-bromo-4-methyl-6-nitrophenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 6627-55-0 2-bromo-p-cresol 

Downstream Products

• 1262298-16-7 C₁₄H₂₀BNO₅ 
• 14151-04-3 3-bromo-2-methoxy-5-methylaniline 

Relevant articles and documents

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

ipso NITRATION. XXIX. NITRATION OF SUBSTITUTED 4-METHYLANISOLES AND PHENOLS

Nitration of 2-chloro-4-methylanisole (1a) in acetic anhydride gives (Z)-4-chloro-3-methoxy-6-methyl-6-nitrocyclohexa-2,4-dienyl acetate (2a), 2-chloro-4-methyl-4-nitrocyclohexa-2,5-dienone (3a), and 2-chloro-4-methyl-6-nitroanisole (4a).Similarly 2-bromo-4-methylanisole (1b) gives (Z)-4-bromo-3-methoxy-6-methyl-6-nitrocyclohexa-2,4-dienyl acetate (2b), 2-bromo-4-methyl-4-nitrocyclohexa-2,5-dienone (3b), and 2-bromo-4-methyl-6-nitroanisole (4b), whereas 4-methyl-2-nitro-anisole (1c) gives (Z)-3-methoxy-6-methyl-4,6-dinitrocyclohexa-2,4-dienyl acetate (2c), (Z)-3-methoxy-6-methyl-2,6-dinitrocyclohexa-2,4-dienyl acetate (7), and 4-methyl-2,6-dinitroanisole (4c).Nitration of 3-chloro-4-methylanisole (9a) gives 3-chloro-4-methyl-4-nitrocyclohexa-2,5-dienone (10a), 3-chloro-4-methyl-2-nitro anisole (11a), and 5-chloro-4-methyl-2-nitroanisole (12a), and 4-methyl-3-nitroanisole (9c) gives (Z)-3-methoxy-6-methyl-5,6-dinitrocyclohexa-2,4-dienyl acetate (13), 4-methyl-2,3-dinitroanisole (11c), and 4-methyl-2,5-dinitroanisole (12c).Nitration of 2-chloro-4-methylphenol (14) in chloroform gives 3a and 2-chloro-4-methyl-6-nitrophenol (5a), and 3-chloro-4-methylphenol (15) gives dienone 10a, 3-chloro-4-methyl-2-nitrophenol (16), and 5-chloro-4-methyl-2-nitrophenol (17).