30439-19-1Relevant articles and documents
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior
Butini, Stefania,Gemma, Sandra,Campiani, Giuseppe,Franceschini, Silvia,Trotta, Francesco,Borriello, Marianna,Ceres, Nicoletta,Ros, Sindu,Coccone, Salvatore Sanna,Bernetti, Matteo,De Angelis, Meri,Brindisi, Margherita,Nacci, Vito,Fiorini, Isabella,Novellino, Ettore,Cagnotto, Alfredo,Mennini, Tiziana,Sandager-Nielsen, Karin,Andreasen, Jesper Tobias,Scheel-Kruger, Jorgen,Mikkelsen, Jens D.,Fattorusso, Caterina
experimental part, p. 151 - 169 (2009/09/25)
Dopamine D3 antagonism combined with serotonin 5-HT1A and 5-HT2A receptor occupancy may represent a novel paradigm for developing innovative antipsychotics. The unique pharmacological features of 5i are a high affinity for
Binding of β-carbolines at 5-HT2 serotonin receptors
Grella, Brian,Teitler, Milt,Smith, Carol,Herrick-Davis, Katharine,Glennon
, p. 4421 - 4425 (2007/10/03)
A series of ring-substituted (i.e., methoxy and bromo) 3,4-dihydro- and 1,2,3,4-tetrahydro-β-carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy-substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected β-carbolines.
